 | San Michele Inn Hotel Sicily | 2.0 star rating | 8 | Catania |
 | San Paolo Palace Hotel Sicily | 4.0 star rating | 280 | Palermo |
 | San Pietro Hotel Sicily | 3.0 star rating | 94 | Taormina Area |
 | San Rocco - One Bedroom Hotel Sicily | Without Official Category | | Catania |
 | Santa Caterina Hotel Sicily | 3.0 star rating | | Catania |
 | Sant Alphio Garden Hotel Sicily | 4.0 star rating | 117 | Taormina Area |
 | Sant Alphio Palace Hotel Sicily | 4.0 star rating | 26 | Lentini |
 | Santa Lucia and Le Sabbie D Oro Hotel Sicily | 3.0 star rating | 256 | Cefalu |
 | Santa Margherita Hotel Sicily | Rural Hotel 4* | 18 | Messina |
 | Santa Tecla Palace Hotel Sicily | 4.0 star rating | 187 | Catania |
 | San Vincenzo Hotel Sicily | 4.0 star rating | 42 | Taormina Area |
| Saracen Sands Resort & Congress Center Sicily | 3.0 star rating | 250 | Palermo |
 | Sataru Resort Sicily | 3.0 star rating | 10 | Trapani |
 | Savona Hotel Sicily | 3.0 star rating | 30 | Catania |
 | Scala Dei Turchi Resort Sicily | Superior 4* | 35 | Agrigento |
| Sclafani - Three Bedroom Hotel Sicily | Without Official Category | | Agrigento |
 | Sea Club Tirreno Hotel Sicily | 3.0 star rating | | Trapani |
 | Sea - Two Bedroom Hotel Sicily | Without Official Category | | Cefalu |
 | Seccagrande - One Bedroom Hotel Sicily | Without Official Category | | Agrigento |
 | Selinunte Beach Hotel Sicily | 4.0 star rating | 135 | Selinunte |
| Seralcadio Bed&Breakfast Hotel Sicily | Bed And Breakfast | 4 | Palermo |
 | Serena - One Bedroom Hotel Sicily | Without Official Category | | Catania |
| Serenusa Village Hotel Sicily | 3.0 star rating | 490 | Caltanissetta |
 | Sferracavallo - Two Bedroom Hotel Sicily | Without Official Category | | Palermo |
| Shalai Resort Sicily | 3.0 star rating | 13 | Catania |
 | Sheraton Catania Hotel Sicily | 4.0 star rating | 169 | Catania |
 | Sigona Grande - Four Bedroom Hotel Sicily | Without Official Category | | Catania |
 | Sikania Hotel Sicily | 3.0 star rating | 25 | Trapani |
 | Sikania Resort & SPA Hotel Sicily | 4.0 star rating | 218 | Caltanissetta |
 | Silvestro - Two Bedroom Hotel Sicily | Without Official Category | | Ragusa |
 | Sirius Hotel Sicily | 4.0 star rating | 41 | Taormina Area |
 | Sky Sleeping Hotel Sicily | Bed And Breakfast | 5 | Palermo |
| Soleado (Sicily - CTA) Hotel | 2.0 star rating | 29 | Siracusa |
 | Sole Castello Hotel Sicily | 3.0 star rating | 54 | Taormina Area |
 | Sole - One Bedroom No.8 Hotel Sicily | Without Official Category | | Ragusa |
 | Soleterraluna Hotel Sicily | Bed And Breakfast | 4 | Trapani |
 | Solsicily Hotel Sicily | Bed And Breakfast | 2 | Catania |
 | Splendid Hotel La Torre Sicily | 1 Star | | Palermo |
 | Sporting Baia Hotel Sicily | 4.0 star rating | 104 | Taormina Area |
 | Stella d'Italia Hotel Sicily | 4.0 star rating | 35 | Marsala |
 | Stesicorea Palace Hotel Sicily | 3.0 star rating | 12 | Catania |
 | Suite City Center Taormina Hotel Sicily | 1 Star | | Taormina Area |
 | Taormina Park Hotel Sicily | 4.0 star rating | | Taormina Area |
| Tartarughe Hotel Sicily | 1 Star | 23 | Taormina Area |
 | Tenuta Stoccatello Hotel Sicily | Rural House | 18 | Agrigento |
 | Tenuta Volpara Hotel Sicily | Rural Hostel 1* | 18 | Trapani |
 | Tenuta Zannafondo Hotel Sicily | Bed And Breakfast | 7 | Ragusa |
 | Tenute Aversa - Four Bedroom Hotel Sicily | Without Official Category | | Trapani |
 | Tenute Plaia Agriturismo Hotel Sicily | Standard | 10 | Trapani |
 | Terra Rossa Residence Hotel Sicily | Without Official Category | | Taormina Area |