 | Marina Holiday Hotel Sicily | 4.0 star rating | 24 | Balestrate |
 | Marina Palace Hotel Spa & Congress Hall Sicily | 4.0 star rating | 53 | Acitrezza Catania |
 | Marina - Three Bedroom Hotel Sicily | Without Official Category | | Siracusa |
 | Marlò - Two Bedroom Hotel Sicily | Without Official Category | | Siracusa |
 | Marsa Siclà - One Bedroom Hotel Sicily | Without Official Category | | Ragusa |
 | Marsa Siclà - One Bedroom No.2 Hotel Sicily | Without Official Category | | Ragusa |
 | Marsa Siclà - Two Bedroom Hotel Sicily | Without Official Category | | Ragusa |
 | Marsa Siclà - Two Bedroom No.3 Hotel Sicily | Without Official Category | | Ragusa |
| Masseria degli Ulivi Hotel Sicily | 3.0 star rating | | Siracusa |
 | Masseria del Piano Hotel Sicily | 3.0 star rating | 14 | Palermo |
 | Massimo Plaza Hotel Sicily | 4.0 star rating | 15 | Palermo |
| Matteotti & Cavour Hotel Sicily | 1 Star | | Cefalu |
 | Mazzaforno Sporting Club Hotel Sicily | 3.0 star rating | 174 | Cefalu |
| Medimare Residence Club Hotel Sicily | Aparthotel 1* | 40 | Isole Eolie |
 | Mediterranee Hotel Sicily | 4.0 star rating | 50 | Taormina Area |
| Mediterraneo Hotel Sicily | 3.0 star rating | 16 | Cefalu |
 | Mediterraneo Palace Hotel Sicily | 3.0 star rating | 92 | Ragusa |
 | Mediterraneo Siracusa Hotel Sicily | 3.0 star rating | 11 | Siracusa |
 | Melina - Three Bedroom No.2 Hotel Sicily | Without Official Category | | Siracusa |
 | Melqart Hotel Sicily | 3.0 star rating | 20 | Agrigento |
 | Mercure Catania Excelsior Hotel Sicily | 4.0 star rating | 176 | Catania |
 | Mercure Palermo Centro Hotel Sicily | 4.0 star rating | 93 | Palermo |
 | Mercure Palermo Excelsior City Hotel Sicily | 4.0 star rating | 116 | Palermo |
 | Mercure Siracusa Prometeo Hotel Sicily | 4.0 star rating | 93 | Siracusa |
 | Meseglise - Two Bedroom Hotel Sicily | Without Official Category | | Ragusa |
| Metropole Maison d'Hôtes Hotel Sicily | 3.0 star rating | 23 | Taormina Area |
 | Michelangelo House Holiday Hotel Sicily | Aparthotel 1* | 2 | Messina |
 | Milazzo Hotel Sicily | 4.0 star rating | 40 | Milazzo |
| Miljunka - Camere e Appartamenti Hotel Sicily | 3.0 star rating | 42 | Cefalu |
 | Milu Beach Club Hotel Sicily | Resort | 41 | Trapani |
 | Mimosa - Two Bedroom Hotel Sicily | Without Official Category | | Trapani |
| Miramare Hotel Sicily | 3.0 star rating | 39 | Catania |
| Miramare Village Hotel Sicily | 3.0 star rating | 43 | Favignana |
 | Moderno Hotel Sicily | 3.0 star rating | 82 | Trapani |
 | Moderno Hotel Sicily | 3.0 star rating | | Trapani |
 | Modica Old Town Rooms Hotel Sicily | 3.0 star rating | 5 | Ragusa |
 | Modica Palace Hotel Sicily | 4.0 star rating | 32 | Ragusa |
 | Monaco Di Mezzo Hotel Sicily | Rural Hostel 1* | | Palermo |
 | Mondello Palace Hotel Sicily | 4.0 star rating | 80 | Palermo |
 | Monte Alto Hotel Sicily | Rural Hostel 1* | 12 | Milazzo |
 | Monte Cofano - Three Bedroom Hotel Sicily | Without Official Category | | Trapani |
 | Montreal Hotel Sicily | 3.0 star rating | 54 | Ragusa |
 | Morgantina Hotel Sicily | 2.0 star rating | 27 | Enna |
 | Mosaici da Battiato Hotel Sicily | 2.0 star rating | 22 | Piazza Armerina |
| Musumeci - Two Bedroom Hotel Sicily | Without Official Category | | Taormina Area |
 | Natalina Hotel Sicily | 2.0 star rating | 21 | Taormina Area |
 | Naxos - One Bedroom Hotel Sicily | Without Official Category | | Giardini Naxos |
 | Nemo - Two Bedroom Hotel Sicily | Without Official Category | | Siracusa |
| Neptun Hotel Sicily | 1 Star | | Cefalu |
 | Nespolo - Three Bedroom Hotel Sicily | Without Official Category | | Catania |