 | Nettuno Catania Hotel Sicily | 4.0 star rating | 101 | Catania |
 | New Charme - Three Bedroom Hotel Sicily | Without Official Category | | Trapani |
| New Palace Hotel Sicily | 5.0 star rating | | Marsala |
 | NH Caltagirone Villa San Mauro Hotel Sicily | 4.0 star rating | 91 | Caltagirone |
 | NH Catania Centro Hotel Sicily | 4.0 star rating | 130 | Catania |
 | NH Catania Parco Degli Aragonesi Hotel Sicily | 4.0 star rating | 123 | Catania |
 | Nh Collection Taormina Hotel Sicily | 5.0 star rating | 63 | Taormina Area |
 | NH Palermo Hotel Sicily | 4.0 star rating | 226 | Palermo |
 | Nicole + Dependance - Four Bedroom Hotel Sicily | Without Official Category | | Trapani |
 | Nifram - Two Bedroom Hotel Sicily | Without Official Category | | Messina |
 | Nike Hotel Sicily | 4.0 star rating | 48 | Taormina Area |
| Nonna Elena Hotel Sicily | Bed And Breakfast | 2 | Trapani |
 | Novecento Hotel Sicily | 3.0 star rating | | Catania |
| Novecento Hotel Sicily | 3.0 star rating | | Ragusa |
 | Nuciara - Three Bedroom Hotel Sicily | Without Official Category | | Giardini Naxos |
| Nyce Club Le Dune Beach Hotel Sicily | 3.0 star rating | 90 | Messina |
 | Oceano&Mare Hotel Sicily | Bed And Breakfast | 5 | Agrigento |
 | Olimpo Hotel Sicily | 4.0 star rating | 310 | Taormina Area |
 | Olimpo & Le Terazze Hotel Sicily | 1 Star | 120 | Taormina Area |
 | Olivella - Three Bedroom Hotel Sicily | Without Official Category | | Cefalu |
 | Ora Resort Phenicusa Filicudi Sicily | 3.0 star rating | 34 | Isole Eolie |
 | Orchidea - Four Bedroom Hotel Sicily | Without Official Category | | Siracusa |
 | Oriente Hotel Sicily | 3.0 star rating | 30 | Isole Eolie |
 | Orizzonte Acireale Hotel Sicily | 4.0 star rating | 131 | Catania |
 | Orologio - Two Bedroom Hotel Sicily | Without Official Category | | Palermo |
| Orsa Maggiore Hotel Sicily | 3.0 star rating | 25 | Isole Eolie |
| Ortigia Cameraconvista Hotel Sicily | Bed And Breakfast | 4 | Siracusa |
 | Ossidiana Stromboli Hotel Sicily | 3.0 star rating | 25 | Isole Eolie |
 | Palazzo Brunaccini Hotel Sicily | 4.0 star rating | 18 | Palermo |
| Palazzo Del Sale Hotel Sicily | 3.0 star rating | 6 | Siracusa |
| Palazzo del Teatro Hotel Sicily | 4 Keys | 4 | Agrigento |
 | Palazzo Ducale Suites Hotel Sicily | Bed And Breakfast | 6 | Palermo |
 | Palazzo Failla Hotel Sicily | 4.0 star rating | 10 | Ragusa |
 | Palazzo Giaraca Hotel Sicily | 3.0 star rating | 25 | Siracusa |
 | Palazzo il Cavaliere B&B de Charme Hotel Sicily | Bed And Breakfast | 8 | Ragusa |
| Palazzo Ossuna Residence Hotel Sicily | Residence | | Trapani |
 | Palazzo Santa Caterina Hotel Sicily | 4.0 star rating | 27 | Taormina Area |
 | Palazzo Zuppello Hotel Sicily | 4.0 star rating | 36 | Siracusa |
 | Palm Beach Hotel Sicily | 3.0 star rating | 40 | Palermo |
| Palmento No.3 Hotel Sicily | Without Official Category | | Catania |
 | Palmento - One Bedroom Hotel Sicily | Without Official Category | | Catania |
 | Paneferrara Hotel Sicily | Villa | 5 | Catania |
 | Panorama Hotel Sicily | 4.0 star rating | 49 | Siracusa |
 | Panoramic Hotel Sicily | 4.0 star rating | 45 | Trapani |
 | Panoramic Hotel Sicily | 3.0 star rating | 23 | Taormina Area |
 | Panoramic Hotel Sicily | 3.0 star rating | 43 | Taormina Area |
 | Papiro No.3 Hotel Sicily | Without Official Category | | Siracusa |
 | Papiro No.6 Hotel Sicily | Without Official Category | | Siracusa |
 | Papiro No.7 Hotel Sicily | Without Official Category | | Siracusa |
 | Papiro - One Bedroom Hotel Sicily | Without Official Category | | Siracusa |