| Residence Capo San Marco & Renella Hotel Sicily | Residence | 25 | Sciacca |
 | Residence Centrum Hotel Sicily | 3.0 star rating | 21 | Trapani |
 | Residence Cicladi - Two Bedroom Hotel Sicily | Without Official Category | | Palermo |
 | Residence Circe Hotel Sicily | 3.0 star rating | 17 | Taormina Area |
 | Residence Hotel Gloria Sicily | 3.0 star rating | 8 | Palermo |
| Residence Il Cantone Del Faro Hotel Sicily | 3.0 star rating | 20 | Messina |
 | Residence La Residenza Hotel Sicily | 3.0 star rating | 28 | Messina |
 | Residence Le Palme Hotel Sicily | 1 Star | 23 | Isole Eolie |
 | Residence Letojanni Hotel Sicily | 3.0 star rating | | Taormina Area |
| Residence Lisola Hotel Sicily | 1 Star | 7 | Favignana |
| Residence Mendolita Hotel Sicily | Residence | 28 | Isole Eolie |
 | Residence Porto Rosa Hotel Sicily | 3.0 star rating | | Milazzo |
 | Residence San Domenico Hotel Sicily | 4.0 star rating | 17 | Trapani |
 | Residence San Marco Hotel Sicily | Without Official Category | | Agrigento |
 | Residence San Marco No.2 Hotel Sicily | Without Official Category | | Agrigento |
 | Residence Smeraldo Hotel Sicily | 3.0 star rating | 14 | Trapani |
 | Residence Villaggio Petruso Hotel Sicily | Residence | 25 | Balestrate |
 | Residence Villa Mare Taormina Hotel Sicily | 3.0 star rating | 25 | Taormina Area |
 | Residenza Wagner Hotel Sicily | Bed And Breakfast | 6 | Palermo |
 | Resort Sole Mediterraneo Sicily | 3.0 star rating | 40 | Agrigento |
 | Rigel Hotel Sicily | 3.0 star rating | 15 | Catania |
 | Rinascita - Three Bedroom Hotel Sicily | Without Official Category | | Palermo |
 | Riposto Taormina Etna Apartment Hotel Sicily | 3 Keys | 2 | Taormina Area |
 | Rita - Four Bedroom Hotel Sicily | Without Official Category | | Trapani |
 | Riva del Sole Hotel Sicily | 3.0 star rating | 116 | Cefalu |
 | Riviera Hotel Sicily | 3.0 star rating | 37 | Trapani |
 | Rocche Draele Hotel Sicily | Rural Hostel 1* | 8 | Trapani |
 | Romano House Hotel Sicily | 4.0 star rating | 50 | Catania |
 | Romano Palace Luxury Hotel Sicily | 5.0 star rating | 104 | Catania |
 | Romeo - One Bedroom Hotel Sicily | Without Official Category | | Ragusa |
 | Rooms Xx Settembre Hotel Sicily | Bed And Breakfast | | Catania |
 | Rosada_Ms - Three Bedroom Hotel Sicily | Without Official Category | | Catania |
| Rosada - Two Bedroom Hotel Sicily | Without Official Category | | Trapani |
 | Rosa - Two Bedroom Hotel Sicily | Without Official Category | | Trapani |
| Rosa - Two Bedroom No.2 Hotel Sicily | Without Official Category | | Siracusa |
 | Rosso Vulcano Hotel Sicily | 3.0 star rating | 4 | Catania |
 | Royal Maniace Hotel Sicily | 4.0 star rating | 21 | Siracusa |
 | Royal Palace Hotel Sicily | 4.0 star rating | 103 | Messina |
 | Ruggero II Hotel Sicily | 4.0 star rating | 53 | Trapani |
 | Ruggiero VII Hotel Sicily | Guest House | 8 | Palermo |
 | Sabbie D'Oro Hotel Sicily | 3.0 star rating | 39 | Taormina Area |
| Sait Hotel Sicily | 3.0 star rating | 22 | Milazzo |
 | Sally - Three Bedroom Hotel Sicily | Without Official Category | | Siracusa |
 | Salvani - One Bedroom Hotel Sicily | Without Official Category | | Ragusa |
 | Sammartano - Four Bedroom Hotel Sicily | Without Official Category | | Marsala |
| San Biagio Resort Sicily | 4.0 star rating | 53 | Catania |
| San Demetrio Hotel Sicily | 2.0 star rating | 6 | Catania |
 | San Domenico Palace Hotel Sicily | 5.0 star rating | 105 | Taormina Area |
 | SAN GIORGIO HOTEL Hotel Sicily | 4.0 star rating | 11 | Ragusa |
 | San Giorgio Palace Hotel Sicily | 3.0 star rating | 7 | Ragusa |