 | Mars Hotel Prague | 3.0 star rating | 50 | Vysocany |
 | Maximilian Hotel Prague | 4.0 star rating | 71 | Stare Mesto |
| Mega Hotel Prague | 3.0 star rating | 16 | Zizkov |
 | Melantrich Sivek Hotels Prague | 3.0 star rating | 24 | Stare Mesto |
 | Meran Hotel Prague | 3.0 star rating | | Vaclavske Namesti |
 | Metamorphis Hotel Prague | 4.0 star rating | 38 | Stare Mesto |
 | Metamorphis Excellent Hotel Prague | 3.0 star rating | 12 | Stare Mesto |
| MH Apartments Central Prague Hotel | 4.0 star rating | 24 | Nove Mesto |
 | Mh Apartments River Prague Hotel | 4.0 star rating | 16 | Andel |
 | Michael Hotel Prague | 4.0 star rating | 53 | Nusle |
| Miss Sophie's Hotel Prague | Aparthotel 4* | 35 | Nove Mesto |
 | Monastery Hotel Prague | 4.0 star rating | 12 | Hradcany |
 | Moods Boutique Hotel Prague | 4.0 star rating | 51 | Stare Mesto |
| Mosaic House Hotel Prague | 4.0 star rating | 90 | Nove Mesto |
 | Mucha Hotel Prague | 4.0 star rating | 39 | Stare Mesto |
 | My Hotel Apollon Prague | 3.0 star rating | 50 | Zizkov |
 | Nh Prague City Hotel | 4.0 star rating | 440 | Andel |
 | Novomestsky Hotel Prague | 3.0 star rating | 34 | Vysocany |
 | Novotel Praha Wenceslas Square Hotel Prague | 4.0 star rating | 146 | Nove Mesto |
 | NYX Prague Hotel | 4.0 star rating | 88 | Stare Mesto |
 | Occidental Praha Hotel Prague | 4.0 star rating | 213 | Nusle |
 | Occidental Praha Five Hotel Prague | 4.0 star rating | 134 | Andel |
 | Occidental Wilson Praha Hotel Prague | 5.0 star rating | 53 | Nove Mesto |
 | Old Prague Hotel | 3.0 star rating | | Stare Mesto |
 | Old Time Hotel Prague | 3.0 star rating | 13 | Nove Mesto |
 | Old Town Residence Hotel Prague | Residence | 6 | Stare Mesto |
 | Old Town Residence Apartments Hotel Prague | 3.0 star rating | 5 | Nove Mesto |
| Old Town Square & Residence Hotel Prague | 5.0 star rating | 10 | Stare Mesto |
 | Olga Hotel Prague | 3.0 star rating | | Holesovice |
 | Olsanka Hotel Prague | 3.0 star rating | 253 | Zizkov |
 | Olympik Hotel Prague | 4.0 star rating | 306 | Stare Mesto |
 | Olympik Artemis Hotel Prague | 3.0 star rating | 50 | Stare Mesto |
 | Olympik Tristar Hotel Prague | 3.0 star rating | 280 | Stare Mesto |
 | Orea Hotel Pyramida Prague | 4.0 star rating | 354 | Hradcany |
 | Ostas Hotel Prague | 3.0 star rating | 32 | Zizkov |
 | Ostruvek Hotel Prague | 3.0 star rating | 63 | Nusle |
 | Otakar Hotel Prague | 3.0 star rating | 41 | Nusle |
 | Pachtuv Palace Hotel Prague | 5.0 star rating | 16 | Stare Mesto |
 | Palac U KoÄků Hotel Prague | 3.0 star rating | 35 | Stare Mesto |
 | Panorama Hotel Prague | 4.0 star rating | 450 | Nusle |
 | Park Holiday Congress & Wellness Hotel Prague | 4.0 star rating | 48 | Stare Mesto |
 | Park Inn Hotel Prague | 4.0 star rating | 210 | Nove Mesto |
| Pension BoB Hotel Prague | 3.0 star rating | | Vysocany |
 | Pension Easy Journey Hotel Prague | 3.0 star rating | 7 | Stare Mesto |
 | Pension Nika Hotel Prague | 3.0 star rating | 7 | Nusle |
 | Pension Prague City Hotel | 3.0 star rating | 54 | Zizkov |
 | Pentahotel Prague Hotel | 4.0 star rating | 227 | Stare Mesto |
 | Pivovar Hotel Prague | 3.0 star rating | 88 | Vysocany |
 | Plaza Alta Hotel Prague | 4.0 star rating | 87 | Holesovice |
 | Plus Prague Hotel | 2.0 star rating | 119 | Holesovice |