 | Erguvan Special Hotel Istanbul | 3.0 star rating | 22 | Old City |
 | Ersu Hotel Istanbul | 3.0 star rating | 38 | Old City |
 | Erten Konak Hotel Istanbul | Boutique | 16 | Old City |
 | Esans Hotel Istanbul | Boutique | 8 | Old City |
| Esen Hotel Istanbul | 3.0 star rating | 35 | Old City |
 | Eser Diamond Hotel & Convention Centre Istanbul | 5.0 star rating | 218 | Marmara |
 | Eser Premium Hotel & Spa Istanbul | 5.0 star rating | 172 | Marmara |
 | Eski Konak Hotel Istanbul | Standard | 9 | Old City |
 | Esra Sultan Petrol Hotel Istanbul | Boutique | 25 | Old City |
| Eternity Hotel Istanbul | 3.0 star rating | 10 | Old City |
 | Eterno Hotel Istanbul | Boutique | 63 | New City |
 | Euro Park Hotel Istanbul | 5.0 star rating | 184 | New City |
| Euro Plaza Hotel Istanbul | 4.0 star rating | 125 | New City |
 | Eurostars Hotel Istanbul | 4.0 star rating | 75 | Old City |
 | Evsen Hotel Istanbul | 3.0 star rating | 27 | Old City |
| Expocity Hotel Istanbul | 3.0 star rating | 29 | Ataturk Airport Istanbul |
 | Express Star Hotel Taksim Istanbul | 3.0 star rating | 27 | New City |
 | Eyfel Hotel Istanbul | 3.0 star rating | 75 | Old City |
 | Faik Pasha Hotels Istanbul | Boutique | 9 | New City |
 | Fairmont Quasar Istanbul Hotel | 5.0 star rating | 209 | New City |
| Family Istanbul Hotel | Boutique | | Old City |
 | Faros Hotel Taksim Istanbul | 4.0 star rating | 30 | New City |
 | Faros Old City Hotel Istanbul | Bed And Breakfast 4* | 23 | Old City |
| Fatih Hotel Corner Istanbul | 3.0 star rating | 22 | New City |
 | Fatih Resadiye Hotel Istanbul | 3.0 star rating | 31 | Old City |
 | Favori Hotel Istanbul | 4.0 star rating | 36 | New City |
 | Fer Hotel Istanbul | 4.0 star rating | 56 | Old City |
 | Ferman Hilal Hotel Istanbul | 3.0 star rating | 30 | New City |
 | Ferman Hotel Istanbul | Boutique | 24 | Old City |
 | Ferman Konak Hotel Istanbul | Without Official Category | 15 | Old City |
 | Ferman Sultan Hotel Istanbul | 3.0 star rating | 19 | Old City |
 | Feronya Hotel Istanbul | 4.0 star rating | 102 | New City |
 | Festinn Suites Golden Horn Hotel Istanbul | 4.0 star rating | 33 | New City |
| Feyza Apartments Hotel Istanbul | Aparthotel 3* | 10 | Old City |
 | Fides Hotel Istanbul Old City | Boutique | 14 | Old City |
 | Fitas Oda Nossa Hotel Istanbul | 3.0 star rating | 12 | New City |
 | Flora Suites Hotel Istanbul | Residence | 110 | Asian Side |
| Florya Konagi Hotel Istanbul | Boutique | 65 | Ataturk Airport Istanbul |
| Florya Park Hotel Istanbul | 3.0 star rating | | Ataturk Airport Istanbul |
 | Flower Palace Hotel Istanbul | Boutique | 36 | Old City |
 | Fors Hotel Istanbul | 3.0 star rating | 19 | Old City |
 | Four Points By Sheraton Batisehir Hotel Istanbul | 4.0 star rating | 144 | Ataturk Airport Istanbul |
 | Four Points By Sheraton Dudullu Istanbul Hotel | 4.0 star rating | 182 | Asian Side |
 | Four Seasons at the Bosphorus Hotel Istanbul | 5.0 star rating | 170 | New City |
 | Four Seasons Hotel Istanbul at Sultanahmet | 5.0 star rating | 65 | Old City |
 | Fraser Place Anthill Istanbul Hotel | Residence | 116 | New City |
 | Fuar Otel Hotel Istanbul | 3.0 star rating | 65 | Old City |
 | Galata Istanbul Hotel | Without Official Category | 22 | Old City |
 | Galata La Bella Hotel Istanbul | Boutique | 27 | Old City |
 | Galata Life Istanbul Hotel | Standard | 5 | New City |