 | Comfort Beige Hotel Istanbul | Boutique | 24 | New City |
| Comfort Elite Hotel Sultanahmet Istanbul | Boutique | 28 | Old City |
 | Comfort Elite Hotles Old City Hotel Istanbul | Boutique | 33 | Old City |
 | Comfort Haramidere Hotel Istanbul | 4.0 star rating | 96 | Ataturk Airport Istanbul |
| Comfort Hotel Taksim Istanbul | Boutique | 21 | New City |
| Comfort Life Hotel Istanbul | 4.0 star rating | 77 | Old City |
 | Conrad Istanbul Bosphorus Hotel | 5.0 star rating | 553 | New City |
 | Cordis Suites Hotel Istanbul | Boutique | 16 | New City |
| Corinne Hotel Istanbul | Boutique | 39 | New City |
 | Corner Hot Hotel Istanbul | Boutique | 10 | New City |
| Corner Living Space Hotel Istanbul | Boutique | 8 | New City |
| Courtyard by Marriott Istanbul Int. Airport Hotel | 4.0 star rating | 264 | Ataturk Airport Istanbul |
 | Cozy Flats Hotel Istanbul | Without Official Category | 19 | New City |
 | Cozy Flats Hotel Istanbul | 3.0 star rating | | Old City |
 | Crowne Plaza Asia Hotel Istanbul | 5.0 star rating | 336 | Asian Side |
 | Crowne Plaza Harbiye Hotel Istanbul | 5.0 star rating | 285 | New City |
 | Crowne Plaza Istanbul - Florya Hotel | 5.0 star rating | 306 | Ataturk Airport Istanbul |
 | Crowne Plaza Istanbul Oryapark Hotel | 5.0 star rating | 197 | Asian Side |
 | Crystal Istanbul Hotel | 4.0 star rating | 185 | New City |
| Cuento Hotel Istanbul | 3.0 star rating | 28 | New City |
 | Cumbali Plaza Hotel Istanbul | 3.0 star rating | 46 | New City |
 | CVK Park Bosphorus Hotel Istanbul | 5.0 star rating | 450 | New City |
 | CVK Taksim Hotel Istanbul | 4.0 star rating | 85 | New City |
 | Dab Hotel Istanbul | 4.0 star rating | 92 | Ataturk Airport Istanbul |
 | Dalan Hotel Istanbul | 3.0 star rating | 64 | Old City |
 | Dalga Residences By Rotana Hotel Istanbul | 5.0 star rating | 161 | Asian Side |
 | Daphne Hotel Istanbul | Boutique | 20 | Old City |
 | Dara Hotel Istanbul | 3.0 star rating | 22 | Old City |
 | Darkhill Hotel Istanbul | 4.0 star rating | 106 | Old City |
 | Darkmen Boutique Hotel Istanbul | Boutique | 25 | Old City |
 | Daru Sultan Hotels Galata Istanbul | Boutique | 35 | New City |
| Day Aparts Hotel Istanbul | Aparthotel 3* | 5 | Ataturk Airport Istanbul |
 | Dedeman Bostanci IstanbulHotel & Convention Centre | 5.0 star rating | 252 | Asian Side |
 | Dedeman Istanbul Hotel | 5.0 star rating | 335 | New City |
| Dedem Boutique Hotel Istanbul | 3.0 star rating | 23 | Old City |
 | Delta Hotel Istanbul | Boutique | 82 | Old City |
 | Deluxe Golden Horn Sultanahmet Hotel Istanbul | 4.0 star rating | 71 | Old City |
| Demirören İstiklal Palas Hotel Istanbul | Boutique | 81 | New City |
 | Deniz Houses Hotel Istanbul | 3.0 star rating | 18 | Old City |
 | Derpa Suite Hotel Osmanbey Istanbul | Boutique | 33 | New City |
| Diamond City Hotels & Resorts Kumburgaz Istanbul | 4.0 star rating | 90 | Marmara |
 | Diamond City Istanbul Hotel | 4.0 star rating | 47 | Ataturk Airport Istanbul |
 | Diamond Royal Hotel Istanbul | Boutique | 23 | Old City |
 | Divani Ali Hotel Istanbul | Boutique | 32 | Old City |
 | Divan Istanbul Asia Airport Hotel | 5.0 star rating | 231 | Asian Side |
 | Divan Istanbul City Hotel | 4.0 star rating | 144 | New City |
 | Divan Istanbul Hotel | 5.0 star rating | 191 | New City |
 | Divan Suites Istanbul Gplus Hotel | 5.0 star rating | 140 | Ataturk Airport Istanbul |
| Divas Boutique Hotel Istanbul | Boutique | 39 | Old City |
| Diyar Hotel Istanbul | Boutique | 17 | Old City |