 | Sky Kamer Hotel Istanbul | 4.0 star rating | 48 | Old City |
 | Sogut Hotel Old City Istanbul | 3.0 star rating | 62 | Old City |
 | Soho House Istanbul Hotel | 5.0 star rating | 87 | New City |
 | Sokullu Pasa Hotel Istanbul | Boutique | 24 | Old City |
 | Sometimes Hotel Taksim Istanbul | 3.0 star rating | 13 | New City |
 | Sorriso Hotel Istanbul | 4.0 star rating | 65 | Old City |
| Sozbir Royal Residence Hotel Istanbul | Boutique | 45 | Asian Side |
| Spectra Hotel Istanbul | Boutique | 16 | Old City |
 | Sphendon Hotel Istanbul | Boutique | 12 | Old City |
 | Spinel Hotel Istanbul | 3.0 star rating | 11 | Old City |
 | Square Suit Aparts Hotel Istanbul | Aparthotel 3* | 9 | Old City |
| Star City Hotel Istanbul | 3.0 star rating | 60 | Old City |
 | Star Holiday Hotel Istanbul | 3.0 star rating | 34 | Old City |
 | Starpark Hotel Istanbul | 3.0 star rating | 59 | Old City |
| Stay Suites Taksim Günlük Apart Hotel Istanbul | 3 Keys | 15 | New City |
 | Steigenberger Airport Hotel Istanbul | 5.0 star rating | 209 | Ataturk Airport Istanbul |
 | Stone Home Old City Hotel Istanbul | Boutique | 10 | Old City |
| Stone Istanbul Hotel | Boutique | 18 | Old City |
 | Stories Hotel Karakol Istanbul | Boutique | 17 | New City |
 | Stories Hotel Kuloglu Istanbul | Boutique | 14 | New City |
 | Stories Hotel Kumbaraci Istanbul | Boutique | 24 | New City |
 | Style Hotel Sisli Istanbul | 4.0 star rating | 74 | New City |
| Suadiye Hotel Istanbul | 5.0 star rating | | New City |
 | Subrosa Hotel Ä°stanbul Istanbul | 3.0 star rating | | Old City |
 | Sude Konak Hotel Istanbul | Boutique | 42 | Old City |
 | Suiteness Taksim Hotel Istanbul | Aparthotel 4* | 40 | New City |
| Sultanahmet Cesme Hotel Istanbul | Boutique | 20 | Old City |
 | Sultanahmet Palace ( Sultanahmet Sarayi ) Hotel Istanbul | Boutique | 45 | Old City |
 | Sultanahmet Park Hotel Istanbul | Boutique | 14 | Old City |
| Sultanahmet Residence Hotel Istanbul | Aparthotel 3* | 22 | Old City |
 | Sultanahmet Star Hotel Istanbul | 3.0 star rating | 24 | Old City |
| Sultanahmet Suites Hotel Istanbul | 4.0 star rating | 26 | Old City |
 | Sultan Corner Suites Hotel Istanbul | 1 Star | 13 | Old City |
 | Sultanhan Boutique Hotel Istanbul | Boutique | 40 | Old City |
 | Sultan House Hotel Istanbul | Boutique | 17 | Old City |
 | Sultania Hotel Istanbul | Boutique | 42 | Old City |
 | Sultan Mehmed Hotel Istanbul | Boutique | 16 | Old City |
 | Sultan Palace Hotel Istanbul | Boutique | 19 | Old City |
 | Sultans Hotel Istanbul | 3.0 star rating | 10 | Ataturk Airport Istanbul |
 | Sultans Royal Hotel Istanbul | 4.0 star rating | 16 | Old City |
| Sultan Suffa Hotel Istanbul | 3.0 star rating | 10 | Old City |
 | Sultan Tughra Hotel Istanbul | 3.0 star rating | 9 | Old City |
 | Sumahan on the Water Hotel Istanbul | Boutique | 13 | Asian Side |
 | Sumengen Hotel Istanbul | Boutique | 25 | Old City |
| Sunlife Hotel Old City Istanbul | Bed And Breakfast | 14 | Old City |
 | Sunlight Hotel Istanbul | 3.0 star rating | 37 | Old City |
 | Sura Design Hotel & Suites Istanbul | Boutique | 60 | Old City |
 | Sura Hagia Sophia Hotel Istanbul | 5.0 star rating | 231 | Old City |
 | Surmeli Hotel Istanbul | 5.0 star rating | 200 | New City |
 | Swissotel The Bosphorus Istanbul Hotel | 5.0 star rating | 566 | New City |