 | Sabra Taxim Suites Hotel Istanbul | Residence | 20 | New City |
| Sahra Airpot Hotel Istanbul | Boutique | 30 | Ataturk Airport Istanbul |
| Salinas Istanbul Hotel | Standard | 20 | Old City |
 | Samil Hotel Istanbul | Boutique | | Old City |
 | Samir Deluxe Hotel Istanbul | 3.0 star rating | 40 | Old City |
 | Sanat Hotel Ä°stanbul Pera Istanbul | 3.0 star rating | 38 | New City |
 | Sanli Suite Hotel Istanbul | 4.0 star rating | 40 | Asian Side |
 | Santa Hill Hotel Istanbul | Boutique | 24 | New City |
 | Santa Ottoman Hotel Istanbul | 4.0 star rating | 20 | New City |
 | Santa Pera Hotel Istanbul | 3.0 star rating | 64 | New City |
 | Santa Sophia Hotel Istanbul | 3.0 star rating | 40 | Old City |
 | Sapphire Hotel Istanbul | Historical Hotel Luxurious | 92 | Old City |
 | Sari Konak Hotel Istanbul | 4.0 star rating | 23 | Old City |
 | Sarnıç Hotel (Ottoman Mansion) Istanbul | Boutique | 16 | Old City |
 | Sarnic Premier Hotel Istanbul | Boutique | 23 | Old City |
| Sayeban Gold Hotel Istanbul | Boutique | 18 | Old City |
 | Sayeban Hotel Istanbul | Standard | 20 | Old City |
| Sea Mansion Suites & Spa Hotel Istanbul | Boutique | 15 | Aksaray |
 | Seatanbul Apart Hotel Istanbul | Aparthotel 2* | 16 | Old City |
 | Sed Hotel Istanbul | 3.0 star rating | 50 | New City |
 | Sehir Hotel Old City Istanbul | 3.0 star rating | 42 | Old City |
 | Selection Suites Istanbul Hotel | 4.0 star rating | 48 | New City |
 | Selenay Hotel Istanbul | 3.0 star rating | 58 | Old City |
| Sembol Hotel Istanbul | 3.0 star rating | 32 | Old City |
 | Seminal Hotel Istanbul | 4.0 star rating | 88 | New City |
 | Semsan Hotel Nisantasi Istanbul | 3.0 star rating | 32 | New City |
 | Senator Hotel Istanbul Old City | 4.0 star rating | 107 | Old City |
 | Senator Taksim Hotel Istanbul | 4.0 star rating | 44 | New City |
 | Senatus Hotel Istanbul | Boutique | 22 | Old City |
 | Septimum Hotel Istanbul | Pending Category | 12 | Old City |
 | Serene Hotel Istanbul | Boutique | 10 | New City |
 | Serenity Hotel Istanbul | 3.0 star rating | 12 | Old City |
 | Serenity Suites Istanbul Airport Hotel | 4.0 star rating | 72 | Ataturk Airport Istanbul |
 | Seres Hotel Istanbul | 4.0 star rating | 54 | Old City |
 | Sevcan Hotel Airport Istanbul | 4.0 star rating | 100 | Ataturk Airport Istanbul |
 | Seven Hills Hotel Istanbul | Boutique | 18 | Old City |
| Seven Hotel Apartments Istanbul | Aparthotel 3* | 30 | Old City |
 | Shangri-La Bosphorus, Istanbul Hotel | 5.0 star rating | 186 | New City |
 | Sheraton Hotel Atakoy Istanbul | 5.0 star rating | 285 | Ataturk Airport Istanbul |
 | Sheraton Istanbul Atasehir Hotel | 5.0 star rating | 165 | Asian Side |
 | Sidonya Hotel Istanbul | 3.0 star rating | 40 | Asian Side |
 | Siesta Hotel Istanbul | 3.0 star rating | 12 | Old City |
 | Silence Istanbul Hotel & Convention Centre | 5.0 star rating | 340 | Asian Side |
 | Sim Hotel Istanbul | 2.0 star rating | 31 | Old City |
 | Simper Hotel Istanbul | 3.0 star rating | 44 | Old City |
 | Sinem Hotel Istanbul | Boutique | 16 | Old City |
 | Sirkeci Mansion Hotel Istanbul | Boutique | 32 | Old City |
 | Sirkeci Park Hotel Istanbul | 3.0 star rating | 24 | Old City |
 | Sirma Sultan Hotel Istanbul | 3.0 star rating | 24 | Old City |
 | Skalion Hotel & Spa Istanbul | 4.0 star rating | 70 | Old City |