 | Dorne Taksim Suite Hotel Istanbul | Aparthotel 3* | 16 | New City |
 | Dosso Dossi Hotels Downtown Istanbul | 5.0 star rating | 139 | Old City |
 | Dosso Dossi Hotels Old City Istanbul | 4.0 star rating | 93 | Old City |
| Doubletree by Hilton Istanbul Avcilar Airport Hotel | 5.0 star rating | 231 | New City |
 | Doubletree by Hilton Istanbul Moda Hotel | 5.0 star rating | 245 | Asian Side |
 | Doubletree by Hilton Istanbul Old Town Hotel | 5.0 star rating | 179 | Old City |
 | Doubletree By Hilton Istanbul Piyalepasa Hotel | 5.0 star rating | 203 | Ataturk Airport Istanbul |
 | Doubletree By Hilton Istanbul Sirkeci Hotel | 4.0 star rating | 113 | Old City |
 | Doubletree By Hilton Istanbul Tuzla Hotel | 4.0 star rating | 84 | Asian Side |
| Dream Bosphorus Hotel Istanbul | Boutique | 25 | Old City |
 | Dream Hill Business Deluxe Hotel Istanbul | 4.0 star rating | 136 | Asian Side |
 | Dualis Hotel Istanbul | Boutique | 10 | Old City |
| Duo Galata Hotel Istanbul | Boutique | 24 | New City |
 | Economic Star Hotel Istanbul | 3.0 star rating | 32 | New City |
 | Edibe Sultan Hotel Istanbul | Boutique | 30 | Old City |
| Efendi Apartment Hotel Istanbul | 3.0 star rating | 3 | Old City |
| Efendi Apartment Gedikpasa Hotel Istanbul | 3 Keys | 5 | Old City |
 | Ekim Apartments Hotel Istanbul | 1 Star | 5 | Old City |
 | Elan Hotel Istanbul | 3.0 star rating | 51 | New City |
| Elanaz Hotel Istanbul | Pending Category | 13 | Ataturk Airport Istanbul |
 | Elegance Asia Hotel Istanbul | Boutique | 50 | Asian Side |
 | Elegance Residence Istanbul Hotel | Boutique | 48 | New City |
| Elibol Hotel Istanbul | Boutique | | Old City |
 | Elite Hotel Darica Istanbul | 5.0 star rating | 194 | Asian Side |
| Elite Hotel Dragos Istanbul | 4.0 star rating | 132 | New City |
| Elite Hotel Kucukyali Istanbul | 3.0 star rating | 81 | Asian Side |
 | Elite Marmara Bosphorus & Suites Hotel Istanbul | Boutique | 16 | New City |
 | Elite Marmara Residence Hotel Istanbul | 3.0 star rating | 44 | Ataturk Airport Istanbul |
 | Elite World Business Hotel Istanbul | 5.0 star rating | 180 | Ataturk Airport Istanbul |
 | Elite World Europe Hotel Istanbul | 5.0 star rating | 401 | Ataturk Airport Istanbul |
 | Elite World Istanbul Hotel | 5.0 star rating | 245 | New City |
 | Elite World Prestige Hotel Istanbul | 4.0 star rating | 102 | New City |
 | Emerald Hotel Istanbul | Superior 4* | 22 | New City |
 | Emin Hotel Istanbul | Standard | 24 | Old City |
 | Emirhan inn Apartment Hotel Istanbul | Aparthotel 3* | 15 | Old City |
 | Emirhan Palace Hotel Istanbul | Boutique | 36 | Avcilar |
| Emmasaray Hotel Istanbul | 3.0 star rating | 12 | Old City |
| Emporium Hotel Istanbul | Boutique | 32 | Old City |
| Enderun Hotel Istanbul | Boutique | 29 | Old City |
 | Endless Art Hotel Istanbul | Boutique | 16 | New City |
 | Endless Hotel Istanbul | Boutique | 17 | New City |
 | Endless Suites Hotel Istanbul | Boutique | 29 | New City |
| En Suites Taksim Hotel Istanbul | Boutique | 8 | New City |
| Ephesus Hotel Istanbul | 3.0 star rating | | Asian Side |
 | Erbazlar Hotel Laleli Istanbul | 3.0 star rating | 24 | Old City |
 | Erbil Hotel Istanbul | 3.0 star rating | 56 | Old City |
 | Erboy Hotel Istanbul | 3.0 star rating | 108 | Old City |
 | Eresin Crown Deluxe Hotel Istanbul | Historical Hotel Luxurious | 59 | Old City |
 | Eresin Taxim Premier Hotel Istanbul | Superior 4* | 67 | New City |
 | Eresin Topkapi Hotel Istanbul | 5.0 star rating | 249 | Old City |