 | Best Western Seven Seas Hotel San Diego - CA | 3.0 star rating | 307 | Mission Valley |
| Candlewood Suites San Diego Hotel San Diego - CA | 3.0 star rating | | Mission Valley |
| Courtyard San Diego Central Hotel San Diego - CA | 3.0 star rating | 245 | Mission Valley |
 | Courtyard San Diego Mission Valley/Hotel Circle San Diego - CA | 4.0 star rating | 317 | Mission Valley |
 | Crowne Plaza San Diego Hotel San Diego - CA | 4.0 star rating | 416 | Mission Valley |
 | Days Inn San Diego Hotel Circle near SeaWorld San Diego - CA | 3.0 star rating | 280 | Mission Valley |
 | Doubletree Club Hotel San Diego San Diego - CA | 4.0 star rating | 219 | Mission Valley |
 | Doubletree Hotel San Diego Mission Valley San Diego - CA | 4.0 star rating | 300 | Mission Valley |
| Hampton Inn San Diego/Mission Valley Hotel San Diego - CA | 2.0 star rating | 184 | Mission Valley |
 | Handlery Hotel San Diego San Diego - CA | 3.0 star rating | 217 | Mission Valley |
 | Hilton Garden Inn San Diego Mission Valley/Stadium Hotel San Diego - CA | 3.0 star rating | 178 | Mission Valley |
 | Hilton San Diego Mission Valley Hotel San Diego - CA | 4.0 star rating | 350 | Mission Valley |
 | Holiday Inn Express San Diego Hotel Circle San Diego - CA | 3.0 star rating | 104 | Mission Valley |
 | Homewood Suites by Hilton San Diego/Mission Valley Hotel San Diego - CA | 3.0 star rating | 118 | Mission Valley |
| Homewood Suites by Hilton San Diego/SeaWorld Area Hotel San Diego - CA | 3.0 star rating | | Mission Valley |
 | Howard Johnson Inn San Diego Hotel Circle San Diego - CA | 2.0 star rating | 80 | Mission Valley |
| Lafayette Hotel San Diego - CA | 3.0 star rating | 131 | Mission Valley |
 | La Quinta San Diego Mission Valley Hotel San Diego - CA | 3.0 star rating | 166 | Mission Valley |
 | Mission Valley Resort San Diego - CA | 2.0 star rating | 220 | Mission Valley |
 | Motel 6 San Diego Hotel Circle San Diego - CA | 2.0 star rating | 204 | Mission Valley |
 | Quality Inn Hotel San Diego - CA | 2.0 star rating | 60 | Mission Valley |
 | Quality Inn Mission Valley Sea World San Diego Hotel San Diego - CA | 3.0 star rating | 126 | Mission Valley |
 | San Diego Marriott Mission Valley Hotel San Diego - CA | 4.0 star rating | 352 | Mission Valley |
 | Sheraton San Diego Mission Valley Hotel San Diego - CA | 4.0 star rating | 260 | Mission Valley |
 | SpringHill Suites by Marriott S.Diego Mission Vall Hotel San Diego - CA | 3.0 star rating | 1 | Mission Valley |
 | Super 8 San Diego Hotel Circle San Diego - CA | 3.0 star rating | 143 | Mission Valley |
 | the Hotel Iris San Diego - CA | 2.0 star rating | 79 | Mission Valley |
 | Town And Country Resort Hotel San Diego - CA | 3.0 star rating | 966 | Mission Valley |