 | Raymond Hotel Istanbul | Boutique | 36 | Old City |
| Raymond Blue Hotel Istanbul | Boutique | 20 | Old City |
 | Real Star Hotel Istanbul | 4.0 star rating | 47 | Old City |
 | Recital Hotel Istanbul | Boutique | 31 | Old City |
 | Reyyan Hotel Istanbul | 3.0 star rating | 19 | Old City |
 | Romance Hotel Istanbul | 4.0 star rating | 63 | Old City |
 | Romantic Hotel Istanbul | Boutique | 9 | Old City |
 | Rose Garden Suites Istanbul Hotel | Boutique | 13 | Old City |
 | Royal Hotel Istanbul | 4.0 star rating | 128 | Old City |
 | Saba Hotel Istanbul | Boutique | 21 | Old City |
 | Saba Sultan Hotel Istanbul | Boutique | 17 | Old City |
| Salinas Istanbul Hotel | Standard | 20 | Old City |
 | Samil Hotel Istanbul | Boutique | | Old City |
 | Samir Deluxe Hotel Istanbul | 3.0 star rating | 40 | Old City |
 | Santa Sophia Hotel Istanbul | 3.0 star rating | 40 | Old City |
 | Sapphire Hotel Istanbul | Historical Hotel Luxurious | 92 | Old City |
 | Sari Konak Hotel Istanbul | 4.0 star rating | 23 | Old City |
 | Sarnıç Hotel (Ottoman Mansion) Istanbul | Boutique | 16 | Old City |
 | Sarnic Premier Hotel Istanbul | Boutique | 23 | Old City |
| Sayeban Gold Hotel Istanbul | Boutique | 18 | Old City |
 | Sayeban Hotel Istanbul | Standard | 20 | Old City |
 | Seatanbul Apart Hotel Istanbul | Aparthotel 2* | 16 | Old City |
 | Sehir Hotel Old City Istanbul | 3.0 star rating | 42 | Old City |
 | Selenay Hotel Istanbul | 3.0 star rating | 58 | Old City |
| Sembol Hotel Istanbul | 3.0 star rating | 32 | Old City |
 | Senator Hotel Istanbul Old City | 4.0 star rating | 107 | Old City |
 | Senatus Hotel Istanbul | Boutique | 22 | Old City |
 | Septimum Hotel Istanbul | Pending Category | 12 | Old City |
 | Serenity Hotel Istanbul | 3.0 star rating | 12 | Old City |
 | Seres Hotel Istanbul | 4.0 star rating | 54 | Old City |
 | Seven Hills Hotel Istanbul | Boutique | 18 | Old City |
| Seven Hotel Apartments Istanbul | Aparthotel 3* | 30 | Old City |
 | Siesta Hotel Istanbul | 3.0 star rating | 12 | Old City |
 | Sim Hotel Istanbul | 2.0 star rating | 31 | Old City |
 | Simper Hotel Istanbul | 3.0 star rating | 44 | Old City |
 | Sinem Hotel Istanbul | Boutique | 16 | Old City |
 | Sirkeci Mansion Hotel Istanbul | Boutique | 32 | Old City |
 | Sirkeci Park Hotel Istanbul | 3.0 star rating | 24 | Old City |
 | Sirma Sultan Hotel Istanbul | 3.0 star rating | 24 | Old City |
 | Skalion Hotel & Spa Istanbul | 4.0 star rating | 70 | Old City |
 | Sky Kamer Hotel Istanbul | 4.0 star rating | 48 | Old City |
 | Sogut Hotel Old City Istanbul | 3.0 star rating | 62 | Old City |
 | Sokullu Pasa Hotel Istanbul | Boutique | 24 | Old City |
 | Sorriso Hotel Istanbul | 4.0 star rating | 65 | Old City |
| Spectra Hotel Istanbul | Boutique | 16 | Old City |
 | Sphendon Hotel Istanbul | Boutique | 12 | Old City |
 | Spinel Hotel Istanbul | 3.0 star rating | 11 | Old City |
 | Square Suit Aparts Hotel Istanbul | Aparthotel 3* | 9 | Old City |
| Star City Hotel Istanbul | 3.0 star rating | 60 | Old City |
 | Star Holiday Hotel Istanbul | 3.0 star rating | 34 | Old City |