| Diyar Hotel Istanbul | Boutique | 17 | Old City |
 | Dosso Dossi Hotels Downtown Istanbul | 5.0 star rating | 139 | Old City |
 | Dosso Dossi Hotels Old City Istanbul | 4.0 star rating | 93 | Old City |
 | Doubletree by Hilton Istanbul Old Town Hotel | 5.0 star rating | 179 | Old City |
 | Doubletree By Hilton Istanbul Sirkeci Hotel | 4.0 star rating | 113 | Old City |
| Dream Bosphorus Hotel Istanbul | Boutique | 25 | Old City |
 | Dualis Hotel Istanbul | Boutique | 10 | Old City |
 | Edibe Sultan Hotel Istanbul | Boutique | 30 | Old City |
| Efendi Apartment Hotel Istanbul | 3.0 star rating | 3 | Old City |
| Efendi Apartment Gedikpasa Hotel Istanbul | 3 Keys | 5 | Old City |
 | Ekim Apartments Hotel Istanbul | 1 Star | 5 | Old City |
| Elibol Hotel Istanbul | Boutique | | Old City |
 | Emin Hotel Istanbul | Standard | 24 | Old City |
 | Emirhan inn Apartment Hotel Istanbul | Aparthotel 3* | 15 | Old City |
| Emmasaray Hotel Istanbul | 3.0 star rating | 12 | Old City |
| Emporium Hotel Istanbul | Boutique | 32 | Old City |
| Enderun Hotel Istanbul | Boutique | 29 | Old City |
 | Erbazlar Hotel Laleli Istanbul | 3.0 star rating | 24 | Old City |
 | Erbil Hotel Istanbul | 3.0 star rating | 56 | Old City |
 | Erboy Hotel Istanbul | 3.0 star rating | 108 | Old City |
 | Eresin Crown Deluxe Hotel Istanbul | Historical Hotel Luxurious | 59 | Old City |
 | Eresin Topkapi Hotel Istanbul | 5.0 star rating | 249 | Old City |
 | Erguvan Special Hotel Istanbul | 3.0 star rating | 22 | Old City |
 | Ersu Hotel Istanbul | 3.0 star rating | 38 | Old City |
 | Erten Konak Hotel Istanbul | Boutique | 16 | Old City |
 | Esans Hotel Istanbul | Boutique | 8 | Old City |
| Esen Hotel Istanbul | 3.0 star rating | 35 | Old City |
 | Eski Konak Hotel Istanbul | Standard | 9 | Old City |
 | Esra Sultan Petrol Hotel Istanbul | Boutique | 25 | Old City |
| Eternity Hotel Istanbul | 3.0 star rating | 10 | Old City |
 | Eurostars Hotel Istanbul | 4.0 star rating | 75 | Old City |
 | Evsen Hotel Istanbul | 3.0 star rating | 27 | Old City |
 | Eyfel Hotel Istanbul | 3.0 star rating | 75 | Old City |
| Family Istanbul Hotel | Boutique | | Old City |
 | Faros Old City Hotel Istanbul | Bed And Breakfast 4* | 23 | Old City |
 | Fatih Resadiye Hotel Istanbul | 3.0 star rating | 31 | Old City |
 | Fer Hotel Istanbul | 4.0 star rating | 56 | Old City |
 | Ferman Hotel Istanbul | Boutique | 24 | Old City |
 | Ferman Konak Hotel Istanbul | Without Official Category | 15 | Old City |
 | Ferman Sultan Hotel Istanbul | 3.0 star rating | 19 | Old City |
| Feyza Apartments Hotel Istanbul | Aparthotel 3* | 10 | Old City |
 | Fides Hotel Istanbul Old City | Boutique | 14 | Old City |
 | Flower Palace Hotel Istanbul | Boutique | 36 | Old City |
 | Fors Hotel Istanbul | 3.0 star rating | 19 | Old City |
 | Four Seasons Hotel Istanbul at Sultanahmet | 5.0 star rating | 65 | Old City |
 | Fuar Otel Hotel Istanbul | 3.0 star rating | 65 | Old City |
 | Galata Istanbul Hotel | Without Official Category | 22 | Old City |
 | Galata La Bella Hotel Istanbul | Boutique | 27 | Old City |
 | Garden House Istanbul Hotel | Boutique | 24 | Old City |
 | Gedik Pasa Konagi Hotel Istanbul | Boutique | 15 | Old City |