 | RETREAT ON HOVE Hotel W. Cape-Cape Town-Garden Route | Bed And Breakfast | 4 | Cape Town |
 | Rivierbos Guest House Hotel W. Cape-Cape Town-Garden Route | 3.0 star rating | 12 | Stellenbosch |
| Road Lodge Cape Town International Airport Hotel W. Cape-Cape Town-Garden Route | 3.0 star rating | | Cape Town International Airport |
 | Romney Park All Suite Hotel & Spa W. Cape-Cape Town-Garden Route | 5.0 star rating | 30 | Cape Town |
| Roosenwijn Guest House Hotel W. Cape-Cape Town-Garden Route | 3.0 star rating | 15 | Stellenbosch |
 | Rosedene Guest House Hotel W. Cape-Cape Town-Garden Route | 3.0 star rating | 15 | Cape Town |
 | Rosenhof Country House Hotel W. Cape-Cape Town-Garden Route | 5.0 star rating | 14 | Oudtshoorn |
 | SANTA MARIA BEACH HOUSE AND SPA Hotel W. Cape-Cape Town-Garden Route | Aparthotel 5* | 4 | Cape Town |
 | Saronsberg Vineyard Cottages Hotel W. Cape-Cape Town-Garden Route | 4.0 star rating | 16 | Tulbagh |
 | Schoone Oordt Country House Hotel W. Cape-Cape Town-Garden Route | 5.0 star rating | 10 | Swellendam |
| Sea Villa Glen Craig Hotel W. Cape-Cape Town-Garden Route | 3.0 star rating | 24 | Pringle Bay |
 | Signal Hill Lodge Hotel W. Cape-Cape Town-Garden Route | 4.0 star rating | 16 | Cape Town |
 | Somerset Villa Hotel W. Cape-Cape Town-Garden Route | 4.0 star rating | 10 | Somerset West |
| Somerton Manor Hotel W. Cape-Cape Town-Garden Route | 4.0 star rating | 10 | Cape Town |
 | South Beach Hotel W. Cape-Cape Town-Garden Route | 5.0 star rating | 19 | Cape Town |
 | Southern Sun Cape Sun Hotel W. Cape-Cape Town-Garden Route | 4.0 star rating | 392 | Cape Town |
 | Southern Sun Cape Town Waterfront Hotel W. Cape-Cape Town-Garden Route | 4.0 star rating | 537 | Cape Town |
 | Southern Sun Cullinan Hotel W. Cape-Cape Town-Garden Route | 4.0 star rating | 394 | Cape Town |
 | Southern Sun Newlands Hotel W. Cape-Cape Town-Garden Route | 4.0 star rating | 162 | Cape Town |
 | Spier Hotel W. Cape-Cape Town-Garden Route | 4.0 star rating | 155 | Stellenbosch |
| StayEasy Century City Hotel W. Cape-Cape Town-Garden Route | 3.0 star rating | 175 | Cape Town |
 | Steenberg Hotel W. Cape-Cape Town-Garden Route | 5.0 star rating | 24 | Cape Town |
 | St. James of Knysna Hotel W. Cape-Cape Town-Garden Route | 5.0 star rating | 15 | Knysna |
 | Strandloper Ocean Lodge Hotel W. Cape-Cape Town-Garden Route | 5.0 star rating | 16 | St Helena Bay |
 | Strand Pavilion Hotel W. Cape-Cape Town-Garden Route | 4.0 star rating | | Somerset West |
 | Strand Tower Hotel W. Cape-Cape Town-Garden Route | 4.0 star rating | 242 | Cape Town |
| Sugar Hotel W. Cape-Cape Town-Garden Route | 3.0 star rating | 7 | Cape Town |
| Sugar Hotel Spa W. Cape-Cape Town-Garden Route | 5.0 star rating | | Cape Town |
 | Sunset-loft Guest House Hotel W. Cape-Cape Town-Garden Route | 3.0 star rating | 5 | Cape Town |
 | Sunsquare Cape Town City Bowl Hotel W. Cape-Cape Town-Garden Route | 3.0 star rating | 202 | Cape Town |
 | Sunsquare Cape Town Gardens Hotel W. Cape-Cape Town-Garden Route | 3.0 star rating | 136 | Cape Town |
 | Sunstays Apartment Hotel W. Cape-Cape Town-Garden Route | 4.0 star rating | 60 | Cape Town |
 | Swartberg Hotel W. Cape-Cape Town-Garden Route | 4.0 star rating | 5 | Oudtshoorn |
 | Sweet Lemon Boutique B&B Hotel W. Cape-Cape Town-Garden Route | 3.0 star rating | 6 | Cape Town |
 | Sweet Ocean View Guest House Hotel W. Cape-Cape Town-Garden Route | 4.0 star rating | 10 | Cape Town |
 | Sweet Olive Guesthouse Hotel W. Cape-Cape Town-Garden Route | 4.0 star rating | 5 | Cape Town |
 | Sweet Orange Guest House Hotel W. Cape-Cape Town-Garden Route | 4.0 star rating | 6 | Cape Town |
 | Taj Cape Town Hotel W. Cape-Cape Town-Garden Route | 5.0 star rating | 176 | Cape Town |
| Tarn Country House Hotel W. Cape-Cape Town-Garden Route | 3.0 star rating | | Plettenberg Bay |
 | Tarragona Lodge Hotel W. Cape-Cape Town-Garden Route | 3.0 star rating | 10 | Cape Town |
 | The Alphen Boutique Hotel W. Cape-Cape Town-Garden Route | 5.0 star rating | 19 | Cape Town |
 | The Andros Deluxe Boutique Hotel W. Cape-Cape Town-Garden Route | 5.0 star rating | 15 | Cape Town |
| The Arniston Spa Hotel W. Cape-Cape Town-Garden Route | 3.0 star rating | 60 | Swellendam |
 | The Bay Hotel W. Cape-Cape Town-Garden Route | 5.0 star rating | 78 | Cape Town |
 | The Bijoux Aparthotel Hotel W. Cape-Cape Town-Garden Route | 4.0 star rating | 27 | Cape Town |
 | The Cape Diamond Boutique Hotel W. Cape-Cape Town-Garden Route | 3.0 star rating | 60 | Cape Town |
 | The Capital mirage Hotel W. Cape-Cape Town-Garden Route | 4.0 star rating | 72 | Cape Town |
 | The Cellars-Hohenort Hotel W. Cape-Cape Town-Garden Route | 5.0 star rating | 52 | Cape Town |
 | The Charles Cafe & Rooms Hotel W. Cape-Cape Town-Garden Route | 3.0 star rating | 11 | Cape Town |
 | The Clarendon Villa Bantry Bay Hotel W. Cape-Cape Town-Garden Route | 5.0 star rating | 11 | Cape Town |