 | Domina Coral Bay Sicilia Zagarella Hotel Sicily | 4.0 star rating | 378 | Palermo |
 | Domus Aurea Hotel Sicily | 4.0 star rating | 20 | Agrigento |
| Domus Hotel Sicily | 3.0 star rating | 18 | Catania |
 | Donnafugata Golf Resort & Spa Sicily | 5.0 star rating | 194 | Ragusa |
 | Donnalucata - One Bedroom Hotel Sicily | Without Official Category | | Ragusa |
 | Donnalucata Resort Sicily | Without Official Category | | Ragusa |
 | Donnalucata Resort Sicily | 3.0 star rating | 108 | Ragusa |
 | Donnalucata Resort - Two Bedroom No.2 Sicily | Without Official Category | | Ragusa |
 | Donnalucata - Two Bedroom Hotel Sicily | Without Official Category | | Ragusa |
 | Donna Rosa Hotel Sicily | 3.0 star rating | 14 | Taormina Area |
 | D'Orange D'Alcantara Hotel Sicily | 3.0 star rating | 50 | Taormina Area |
| Dream House - Six Bedroom Hotel Sicily | Without Official Category | | Trapani |
 | Eden Riviera Hotel Sicily | 3.0 star rating | 28 | Catania |
| Edera - Two Bedroom No.2 Hotel Sicily | Without Official Category | | Trapani |
| Elena No.11 Hotel Sicily | Without Official Category | | Catania |
 | El Homs Palace Hotel Sicily | 1 Star | 20 | Ragusa |
 | Elios Hotel Sicily | 2.0 star rating | 22 | Taormina Area |
 | Eliseo Hotel Sicily | 2.0 star rating | 13 | Taormina Area |
 | El Jebel Hotel Sicily | 3.0 star rating | 10 | Taormina Area |
 | Emmaus Hotel Sicily | 3.0 star rating | 75 | Catania |
 | Eolian Milazzo Hotel Sicily | 4.0 star rating | 46 | Milazzo |
 | Eracle Hotel Sicily | 4.0 star rating | 36 | Trapani |
| Eremo Della Giubiliana Hotel Sicily | Pending Category | 24 | Ragusa |
 | Erice Hotel Sicily | 3.0 star rating | 32 | Trapani |
 | Ermes - Three Bedroom Hotel Sicily | Without Official Category | | Catania |
 | EROS Hotel Sicily | 4.0 star rating | 25 | Isole Eolie |
| Esmeral - Three Bedroom Hotel Sicily | Without Official Category | | Trapani |
 | Esperia Palace Hotel Sicily | Superior 4* | 42 | Catania |
 | Esperidi Park Hotel Sicily | 4.0 star rating | 99 | Castelvetrano |
 | Etna Hotel Sicily | 4.0 star rating | 30 | Catania |
| Etna B&B Hotel Sicily | 3.0 star rating | | Catania |
 | Etna Golf Resort Sicily | Superior 4* | 98 | Taormina Area |
 | Etna Massalargia Hotel Sicily | Bed And Breakfast | 4 | Catania |
 | Eureka Palace Hotel Spa Resort Sicily | 5.0 star rating | 106 | Siracusa |
 | Eureka - Three Bedroom Hotel Sicily | Without Official Category | | Siracusa |
 | Europa Hotel Sicily | 3.0 star rating | 71 | Palermo |
 | Europa Palace Hotel Sicily | 3.0 star rating | 109 | Messina |
 | Eurostars Centrale Palace Hotel Sicily | 4.0 star rating | 102 | Palermo |
 | Eurostars Monte Tauro Hotel Sicily | 4.0 star rating | 100 | Taormina Area |
 | Excelsior Palace Hotel Sicily | 4.0 star rating | 88 | Taormina Area |
 | Excelsior Palace Terme Hotel Sicily | 3.0 star rating | 229 | Catania |
 | Falconara Charming House Hotel Sicily | 4.0 star rating | 65 | Caltanissetta |
 | Fallico - One Bedroom Hotel Sicily | Without Official Category | | Catania |
 | Fallico - One Bedroom No.2 Hotel Sicily | Without Official Category | | Catania |
 | Favatella - One Bedroom Hotel Sicily | Without Official Category | | Catania |
 | Federico II Hotel Sicily | 4.0 star rating | 30 | Messina |
 | Federico II Hotel Sicily | 3.0 star rating | 9 | Catania |
 | Ferrini Home Hotel Sicily | Aparthotel 1* | 13 | Catania |
 | Ferrini Home Residence 150 Hotel Sicily | Apartment 1st Category | 12 | Catania |
 | Ferro Hotel Sicily | 4.0 star rating | 21 | Ragusa |