 | Cielo - Two Bedroom Hotel Sicily | Without Official Category | | Giardini Naxos |
 | Città Del Mare Hotel Village Sicily | 3.0 star rating | 800 | Palermo |
 | Ciuri Di Badia Hotel Sicily | 3.0 star rating | 48 | Trapani |
 | CIURI HOME Hotel Sicily | Apartment 2nd Category | 10 | Trapani |
 | Claudia Hotel Sicily | Without Official Category | | Siracusa |
 | Club Costa Verde Hotel Sicily | 4.0 star rating | 380 | Cefalu |
 | Club Eloro Hotel Sicily | 3.0 star rating | 20 | Siracusa |
 | Club Helios Hotel Sicily | 3.0 star rating | 143 | Siracusa |
 | Colle San Mauro Hotel Sicily | Rural Hostel 1* | 25 | Caltagirone |
| Colleverde Park Hotel Sicily | 4.0 star rating | 48 | Agrigento |
 | Columbia Hotel Sicily | 2.0 star rating | 23 | Palermo |
| Como Siracusa Hotel Sicily | 3.0 star rating | 18 | Siracusa |
 | Conchigliad'Oro Hotel Sicily | 3.0 star rating | 50 | Palermo |
 | Continental Hotel Sicily | Superior 3* | 32 | Taormina Area |
 | Corallo Hotel Sicily | 4.0 star rating | 16 | Taormina Area |
 | Cornino - Three Bedroom Hotel Sicily | Without Official Category | | Trapani |
 | Cortile Antico Hotel Sicily | 1 Star | 8 | Trapani |
 | Costa Azul Hotel Sicily | 4.0 star rating | 18 | Balestrate |
 | Costa Del Sole Hotel Sicily | 3.0 star rating | 22 | Catania |
 | Costa Makauda Residence Hotel Sicily | Residence | 82 | Agrigento |
 | Costazzurra Hotel Sicily | 4.0 star rating | 30 | Agrigento |
 | Cottage - Two Bedroom Hotel Sicily | Without Official Category | | Ragusa |
 | Cristal Palace Hotel Sicily | 4.0 star rating | 80 | Palermo |
 | Crystal Hotel Sicily | 4.0 star rating | 70 | Trapani |
 | Crystal Sea Hotel Sicily | 4.0 star rating | 39 | Taormina Area |
 | Cutimare Hotel Sicily | 4.0 star rating | 30 | Isole Eolie |
 | Cycas - Five Bedroom Hotel Sicily | Without Official Category | | Isole Eolie |
| Da Gianni E Lucia Hotel Sicily | Bed And Breakfast | 6 | Catania |
 | Dammino - Nine Bedroom Hotel Sicily | Without Official Category | | Ragusa |
| Daria Hotel in Cefalu Sicily | 1 Star | 258 | Cefalu |
 | De Curtis Palace Bed and Breakfast Hotel Sicily | Bed And Breakfast | 12 | Catania |
 | Degli Angeli Hotel Sicily | 3.0 star rating | 28 | Butera |
 | Dei Pini Hotel Sicily | 4.0 star rating | 130 | Agrigento |
 | Del Corso Hotel Sicily | 1 Star | 22 | Taormina Area |
 | Delfino Beach Hotel Sicily | 4.0 star rating | 243 | Marsala |
 | Della Valle Hotel Sicily | 4.0 star rating | 120 | Agrigento |
 | delle Palme Hotel Sicily | 3.0 star rating | 50 | Taormina Area |
| Del Santuario Hotel Sicily | 3.0 star rating | 73 | Siracusa |
 | Del Viale Hotel Sicily | 3.0 star rating | 20 | Agrigento |
 | Demetra Resort Sicily | Superior 4* | 2 | Agrigento |
 | Des Etrangers Hotel & SPA Sicily | 5.0 star rating | 77 | Siracusa |
 | De Stefano Palace - Luxury Hotel Sicily | Superior 4* | 14 | Ragusa |
| Desusino Park Village & Hotel Sicily | 3.0 star rating | 60 | Caltanissetta |
 | Diamond Hotel and Resort Naxos Taormina Sicily | 5.0 star rating | 115 | Taormina Area |
 | Dimora Annulina Room & Breakfast Hotel Sicily | Bed And Breakfast | 6 | Palermo |
 | Dimora Delletna Hotel Sicily | Bed And Breakfast | 3 | Catania |
 | Dioscuri Bay palace Hotel Sicily | 4.0 star rating | 102 | Agrigento |
 | Disio Resort Sicily | 4.0 star rating | 23 | Trapani |
| Dolce Casa Hotel Sicily | 3.0 star rating | 10 | Siracusa |
 | Dolce Vita B&B Hotel Sicily | Bed And Breakfast 3* | 4 | Cefalu |