 | Casa Del Capo - One Bedroom No.2 Hotel Sicily | Without Official Category | | Palermo |
 | Casa Del Capo - One Bedroom No.3 Hotel Sicily | Without Official Category | | Palermo |
 | Casa Del Ficus B&B Hotel Sicily | Bed And Breakfast | 4 | Catania |
| Casa Giuditta Palermo Central Hotel Sicily | 1 Star | 10 | Palermo |
 | Casa La Sauna Hotel Sicily | Apartment 3rd Category | 3 | Agrigento |
 | Casal Di Noto Resort Sicily | 4.0 star rating | 14 | Siracusa |
 | Casale Romano Hotel Sicily | 3.0 star rating | 11 | Taormina Area |
 | Casa Mandorlo Hotel Sicily | 1 Star | | Cefalu |
 | Casa Marconi BB Hotel Sicily | 3.0 star rating | 83 | Palermo |
| Casa Mare Hotel Sicily | Without Official Category | | Siracusa |
 | Casa Orioles Hotel Sicily | 3.0 star rating | 5 | Palermo |
 | Casa Palme - Three Bedroom Hotel Sicily | Without Official Category | | Agrigento |
| Casa Ruffino Hotel Sicily | Bed And Breakfast | 5 | Balestrate |
 | Casa Sul Canale - Two Bedroom Hotel Sicily | Without Official Category | | Messina |
 | Casa Tina Maugeri B&B Hotel Sicily | Bed And Breakfast | 4 | Catania |
 | Casato Licitra Hotel Sicily | 4.0 star rating | 8 | Ragusa |
| Casatrapani B&B E Appartamenti Hotel Sicily | Bed And Breakfast | 6 | Trapani |
 | Casa - Two Bedroom No.2 Hotel Sicily | Without Official Category | | Siracusa |
 | Casa Ulivo Cefalu Hotel Sicily | 1 Star | | Cefalu |
| Casa Vacanza Marina Bay Hotel Sicily | Without Official Category | | Trapani |
 | Casa Vacanze Fardella Centrale Hotel Sicily | Residence | 9 | Trapani |
 | Casa Vacanze Perla Rosa Hotel Sicily | 1 Star | 18 | Trapani |
| Casa Vacanze Porta Carini Hotel Sicily | 3.0 star rating | 8 | Palermo |
 | Case Damma Hotel Sicily | 3.0 star rating | 10 | Siracusa |
 | Case Francesco Hotel Sicily | Bed And Breakfast | 3 | Ragusa |
 | Casena dei Colli Hotel Sicily | 3.0 star rating | 93 | Palermo |
 | Case Vacanze Bellavista Hotel Sicily | 3.0 star rating | 28 | Agrigento |
 | Case Vacanze Trabinis Hotel Sicily | Guest House | 11 | Trapani |
 | Cassisi Hotel Sicily | 4.0 star rating | 17 | Messina |
 | Castagneto Dell Etna Hotel Sicily | Bed And Breakfast | 3 | Catania |
 | Castello Camemi Hotel Sicily | 3.0 star rating | 14 | Caltagirone |
| Castello Di San Marco Hotel & Spa Sicily | Superior 4* | 30 | Taormina Area |
 | Castiglia Hotel Sicily | Bed And Breakfast | 5 | Palermo |
 | Catania Centro Rooms Hotel Sicily | 3.0 star rating | 12 | Catania |
 | Catania International Airport Hotel Sicily | 4.0 star rating | 208 | Catania |
 | Catarina - Four Bedroom Hotel Sicily | Without Official Category | | Cefalu |
 | Cava - One Bedroom Hotel Sicily | Without Official Category | | Ragusa |
 | Cava - Two Bedroom Hotel Sicily | Without Official Category | | Ragusa |
 | Cava - Two Bedroom No.2 Hotel Sicily | Without Official Category | | Ragusa |
 | Cave Bianche Hotel Sicily | 4.0 star rating | 32 | Favignana |
 | Cefalu Sea Palace Hotel Sicily | 1 Star | 83 | Cefalu |
 | Centrale Hotel Sicily | 4.0 star rating | 32 | Trapani |
| Centrale Hotel Sicily | 3.0 star rating | 24 | Siracusa |
 | Cerri Hotel Sicily | 3.0 star rating | 30 | Trapani |
 | Cetarium Hotel Sicily | 4.0 star rating | 26 | Trapani |
 | Chalet - One Bedroom Hotel Sicily | Without Official Category | | Siracusa |
 | Charlotte House - Two Bedroom Hotel Sicily | Without Official Category | | Agrigento |
 | Charlotte House - Two Bedroom No.2 Hotel Sicily | Without Official Category | | Agrigento |
 | Chicchi Di Melograno Hotel Sicily | Bed And Breakfast | 4 | Ragusa |
| Cielo Mare Hotel Sicily | Residence | 11 | Trapani |