 | Sienna Resort Santorini | Resort | 6 | Fira |
 | Sigalas Hotel Santorini | Aparthotel 3* | 22 | Fira |
| Silver Palace Hotel Santorini | 3.0 star rating | 14 | Perissa-Perivolos |
 | Skyfall Suites Hotel Santorini | 4.0 star rating | 17 | Pyrgos |
 | Solaris Hotel Santorini | 4 Keys | 18 | Fira |
 | Sophia Luxury Suites Hotel Santorini | 4 Keys | 18 | Imerovigli |
 | Spiliotica on the Cliff Hotel Santorini | 3 Keys | 24 | Imerovigli |
 | Splendour Resort Santorini | 5.0 star rating | 59 | Firostefani |
 | Star Hotel Santorini | 2.0 star rating | 44 | Megalochori |
 | Stavros Villas Hotel Santorini | 3.0 star rating | 13 | Fira |
 | Strogili Hotel Santorini | 3.0 star rating | | Kamari |
 | Studios Marios Hotel Santorini | 3 Keys | 16 | Kamari |
 | Suites Blue Hotel and Spa Santorini | 4.0 star rating | 25 | Fira |
 | Suites of the Gods Hotel Santorini | 4.0 star rating | 22 | Megalochori |
| Sunflower Hotel Santorini | 3.0 star rating | | Kamari |
 | Sunny Villas Apartments Hotel Santorini | 4 Keys | 17 | Imerovigli |
 | Sunrise Hotel Santorini | 2.0 star rating | 26 | Fira |
 | Sunrise Studios Perissa Hotel Santorini | 3 Keys | 9 | Perissa-Perivolos |
 | Sun Rocks Boutique Hotel Santorini | 5.0 star rating | 18 | Firostefani |
 | Sunshine Hotel Santorini | 3.0 star rating | 35 | Kamari |
 | Sweet Tweet Hotel Santorini | Bed And Breakfast | 7 | Perissa-Perivolos |
 | Tamarix Del Mar Hotel Santorini | 5.0 star rating | 25 | Kamari |
 | Tataki Hotel Santorini | 2.0 star rating | 13 | Fira |
 | Terra Blue Santorini Hotel | 3.0 star rating | 44 | Kamari |
 | Thalassa Seaside Resort & Suites Santorini | 3.0 star rating | 59 | Kamari |
 | The Armonia Hotel Santorini | 3.0 star rating | 30 | Kamari |
| Thea Studios Hotel Santorini | 4 Keys | 16 | Fira |
 | The Dream Villas Hotel Santorini | 5.0 star rating | 2 | Oia |
 | The Ivory Suite Hotel Santorini | Villa | 4 | Oia |
 | The Museum Spa Wellness Hotel Santorini | 3.0 star rating | 9 | Oia |
 | Theoxenia Boutique Hotel Santorini | 3.0 star rating | 9 | Fira |
| The Phenix Hotel Santorini | 4 Keys | | Imerovigli |
 | Thera Mare Hotel Santorini | 3.0 star rating | 32 | Perissa-Perivolos |
 | Thermes Luxury Villas Hotel Santorini | 4.0 star rating | 7 | Megalochori |
 | Thermes Saint Alexander Villas Hotel Santorini | 4.0 star rating | 3 | Messaria |
 | The Vasilicos Caldera Heritage Suites Hotel Santorini | 5.0 star rating | 7 | Imerovigli |
 | Thira's Dolphin Hotel Santorini | 3 Keys | 12 | Akrotiri |
| Thireas Hotel Santorini | 5.0 star rating | 7 | Fira |
 | Tholos Resort Santorini | 4.0 star rating | 12 | Imerovigli |
 | Timedrops Santorini Hotel | 5.0 star rating | 18 | Emporeio |
 | Trieris Villas & Suites Hotel Santorini | 5.0 star rating | 3 | Fira |
 | Tzekos Villas Hotel Santorini | 4.0 star rating | 20 | Fira |
 | Vedema Resort Santorini | 5.0 star rating | 45 | Megalochori |
 | Veggera Hotel Santorini | 4.0 star rating | 73 | Perissa-Perivolos |
| VILLA AGROIKIA Hotel Santorini | 5.0 star rating | | Oia |
 | Villa Anemomilos Hotel Santorini | 3 Keys | 14 | Perissa-Perivolos |
 | Villa Anemoni Hotel Santorini | 1 Star | 10 | Fira |
 | Villa Angira Hotel Santorini | 3 Keys | 14 | Kamari |
 | Villa Anneta Hotel Santorini | 2 Keys | 15 | Kamari |
 | Villa Calliope Hotel Santorini | Villa | 1 | Oia |