 | Sheraton San Diego Hotel & Marina San Diego - CA | 4.0 star rating | 1053 | Downtown/Gaslamp District |
 | Sheraton San Diego Mission Valley Hotel San Diego - CA | 4.0 star rating | 260 | Mission Valley |
 | Solamar A Kimpton Hotel San Diego - CA | 4.0 star rating | 235 | Downtown/Gaslamp District |
 | Sommerset Suites San Diego Hotel San Diego - CA | 2.0 star rating | 80 | Hillcrest |
| Sonoran Suites of San Diego Hotel San Diego - CA | 3.0 star rating | | Carlsbad - Oceanside |
 | South Coast Winery Resort and Spa San Diego - CA | 3.0 star rating | 126 | Temecula |
| Southern California Beach Club Resort Condos San Diego - CA | 3.0 star rating | 43 | Oceanside |
| SpringHill Suites by Marriott San Diego Downtown/B Hotel San Diego - CA | 3.0 star rating | 253 | Downtown/Gaslamp District |
 | SpringHill Suites by Marriott S.Diego Mission Vall Hotel San Diego - CA | 3.0 star rating | 1 | Mission Valley |
 | SpringHill Suites San Diego Oceanside/Downtown Hotel San Diego - CA | 3.0 star rating | | Oceanside |
| SpringHill Suites San Diego Rancho Bernardo Hotel San Diego - CA | 3.0 star rating | 137 | Poway |
 | SpringHill Suites Temecula Valley Wine Country Hotel San Diego - CA | 3.0 star rating | 134 | Temecula |
| Staybridge Suites Carlsbad Hotel San Diego - CA | Without Official Category | | Carlsbad Airport |
| Staybridge Suites San Diego Rancho Bernardo Hotel San Diego - CA | 4.0 star rating | 116 | North San Diego |
 | Staybridge Suites San Diego-Sorrento Mesa Hotel San Diego - CA | 4.0 star rating | 131 | North San Diego |
 | Staybridge Suites Sorrento Mesa Hotel San Diego - CA | 3.0 star rating | | North San Diego |
 | Sunshine Suites - La Jolla Hotel San Diego - CA | 3.0 star rating | 4 | La Jolla |
 | Super 8 Hotel San Diego - CA | 2.0 star rating | 47 | El Cajon - La Mesa |
 | Super 8 Motel - Escondido Hotel San Diego - CA | 3.0 star rating | 75 | Escondido - Wild Animal Park |
| Super 8 National City Chula Vista Hotel San Diego - CA | Without Official Category | | Chula Vista |
 | Super 8 Oceanside Hotel San Diego - CA | 2.0 star rating | 106 | Carlsbad - Oceanside |
 | Super 8 San Diego Hotel Circle San Diego - CA | 3.0 star rating | 143 | Mission Valley |
 | Super 8 San Diego Imperial Beach Hotel San Diego - CA | 2.0 star rating | 61 | Imperial Beach Area |
| Surfer Beach Hotel San Diego - CA | 3.0 star rating | 53 | Pacific Beach |
 | Surf Motel - Carlsbad Hotel San Diego - CA | 3.0 star rating | | Carlsbad - Oceanside |
 | Tamarack Beach Resort Hotel San Diego - CA | 3.0 star rating | | Carlsbad - Oceanside |
 | Temecula Creek Inn Hotel San Diego - CA | 4.0 star rating | 130 | Temecula |
 | the Hotel Iris San Diego - CA | 2.0 star rating | 79 | Mission Valley |
 | The Inn at Rancho Santa Fe Hotel San Diego - CA | 3.0 star rating | 80 | Del Mar |
| The Keating Hotel San Diego - CA | 4.0 star rating | 35 | Downtown/Gaslamp District |
 | The Lodge at Torrey Pines Hotel San Diego - CA | 5.0 star rating | 170 | Torrey Pines |
| The Pearl Hotel San Diego - CA | 3.0 star rating | 23 | San Diego International Airport |
 | The Sofia Hotel San Diego - CA | 3.0 star rating | 211 | Downtown/Gaslamp District |
 | The US Grant Hotel San Diego - CA | 4.0 star rating | 270 | Downtown/Gaslamp District |
 | The Westin San Diego Hotel San Diego - CA | 3.0 star rating | 436 | Downtown/Gaslamp District |
 | Tower23 Hotel San Diego - CA | 5.0 star rating | 44 | Mission Bay-Sea World |
 | Town And Country Resort Hotel San Diego - CA | 3.0 star rating | 966 | Mission Valley |
| TownePlace San Diego Carlsbad/Vista Hotel San Diego - CA | 3.0 star rating | 94 | San Marcos area |
 | Travelodge Hotel San Diego - CA | 3.0 star rating | 43 | El Cajon - La Mesa |
 | Travelodge La Mesa Hotel San Diego - CA | 3.0 star rating | 57 | El Cajon - La Mesa |
 | Travelodge Oceanside Hotel San Diego - CA | 2.0 star rating | 80 | Oceanside |
| Travelodge San Diego Downtown Convention Center Hotel San Diego - CA | 3.0 star rating | 42 | Downtown/Gaslamp District |
 | Travelodge San Diego SeaWorld Hotel San Diego - CA | 2.0 star rating | 46 | Oceanside |
 | Travelodge San Ysidro Hotel San Diego - CA | 3.0 star rating | 97 | San Ysidro |
| Urban Boutique Hotel San Diego - CA | 3.0 star rating | 55 | Downtown/Gaslamp District |
 | Villa Serena Motel El Cajon Hotel San Diego - CA | 3.0 star rating | 24 | El Cajon - La Mesa |
 | Villas On The Greens At The Welk Resort San Diego - CA | 4.0 star rating | | Escondido - Wild Animal Park |
 | Wave Crest Hotel San Diego - CA | 3.0 star rating | | Del Mar |
| Welcome Inn Corona Hotel San Diego - CA | 3.0 star rating | 59 | Coronado |
 | Western Inn Hotel San Diego - CA | 2.0 star rating | 35 | Old Town |