 | Hampton Inn Anderson Hotel Spartanburg - Greenville - SC | 3.0 star rating | 71 | Greenville |
 | Hampton Inn Anderson/ Alliance Business Park Hotel Spartanburg - Greenville - SC | 3.0 star rating | 79 | Greenville |
 | Hampton Inn and Suites Greenville-Downtown, SC Hotel Spartanburg - Greenville - SC | 3.0 star rating | 115 | Greenville |
| Hampton Inn and Suites Seneca, SC Hotel Spartanburg - Greenville - SC | 5.0 star rating | 100 | Seneca |
 | Hampton Inn Clemson Hotel Spartanburg - Greenville - SC | 3.0 star rating | 90 | Clemson |
 | Hampton Inn Easley Hotel Spartanburg - Greenville - SC | 3.0 star rating | 81 | Greenville |
 | Hampton Inn Gaffney Hotel Spartanburg - Greenville - SC | 3.0 star rating | 85 | Spartanburg |
 | Hampton Inn Greenville Haywood Hotel Spartanburg - Greenville - SC | 2.0 star rating | 86 | Greenville |
 | Hampton Inn Greenville I-385 - Woodruff Rd. Hotel Spartanburg - Greenville - SC | 3.0 star rating | 115 | Greenville |
 | Hampton Inn Greenville- Simpsonville Hotel Spartanburg - Greenville - SC | 3.0 star rating | 84 | Greenville |
 | Hampton Inn Greenville/Travelers Rest Hotel Spartanburg - Greenville - SC | 3.0 star rating | 61 | Greenville |
 | Hampton Inn Spartanburg-North I-85 Hotel Spartanburg - Greenville - SC | 3.0 star rating | 86 | Spartanburg |
 | Hampton Inn & Suites Clinton Hotel Spartanburg - Greenville - SC | 3.0 star rating | 100 | Spartanburg |
 | Hampton Inn & Suites Greenville Airport, SC Hotel Spartanburg - Greenville - SC | 2.0 star rating | 127 | Piedmont |
 | Hampton Inn & Suites Greenville-Spartanburg Hotel Spartanburg - Greenville - SC | 3.0 star rating | 133 | Spartanburg |
 | Hampton Inn & Suites Spartanburg-I-26-Westgate Hotel Spartanburg - Greenville - SC | 3.0 star rating | 126 | Spartanburg |
 | Hawthorn Suites by Wyndham Greenville Hotel Spartanburg - Greenville - SC | 3.0 star rating | | Greenville |
 | Hilton Garden Inn Anderson Hotel Spartanburg - Greenville - SC | 3.0 star rating | 124 | Clemson |
 | Hilton Garden Inn Greenville Hotel Spartanburg - Greenville - SC | 3.0 star rating | 120 | Greenville |
 | Hilton Greenville Hotel Spartanburg - Greenville - SC | 4.0 star rating | 256 | Greenville |
| Holiday Inn Anderson Hotel Spartanburg - Greenville - SC | 3.0 star rating | | Anderson |
| Holiday Inn Express Anderson-I-85 (Exit 27-Highway Hotel Spartanburg - Greenville - SC | 3.0 star rating | 63 | Greenville |
| Holiday Inn Express and Suites Anderson I 85 Hwy 7 Hotel Spartanburg - Greenville - SC | 3.0 star rating | | Clemson |
| Holiday Inn Express and Suites Greenville Airport Hotel Spartanburg - Greenville - SC | 3.0 star rating | | Piedmont |
| Holiday Inn Express and Suites Greenville Downtown Hotel Spartanburg - Greenville - SC | 3.0 star rating | | Piedmont |
| Holiday Inn Express and Suites Greenville I 85 and Hotel Spartanburg - Greenville - SC | 3.0 star rating | | Greenville |
| Holiday Inn Express Greer Taylors at Us 29 Hotel Spartanburg - Greenville - SC | 3.0 star rating | | Greer |
| Holiday Inn Express Hotel & Suites Clemson - Univ Spartanburg - Greenville - SC | 3.0 star rating | 93 | Clemson |
| Holiday Inn Express Hotel & Suites Duncan Spartanburg - Greenville - SC | 3.0 star rating | 75 | Greenville |
| Holiday Inn Express Hotel & Suites Greenville Down Spartanburg - Greenville - SC | 3.0 star rating | | Greenville |
| Holiday Inn Express Hotel & Suites Greenville I-85 Spartanburg - Greenville - SC | 3.0 star rating | | Greenville |
| Holiday Inn Express Simpsonville Hotel Spartanburg - Greenville - SC | 3.0 star rating | 87 | Greenville |
| Holiday Inn Express Spartanburg-North Hotel Spartanburg - Greenville - SC | 3.0 star rating | 91 | Spartanburg |
| Holiday Inn Express & Suites I-26 & US 29 at Westg Hotel Spartanburg - Greenville - SC | 3.0 star rating | | Spartanburg |
 | Home2 Suites by Hilton Greenville Airport, SC Hotel Spartanburg - Greenville - SC | 3.0 star rating | 102 | Spartanburg |
| Home2 Suites by Hilton Greenville Downtown, SC Hotel Spartanburg - Greenville - SC | 3.0 star rating | 117 | Piedmont |
| Home-Towne Suites Hotel Spartanburg - Greenville - SC | 3.0 star rating | 79 | Anderson |
 | Homewood Suites - Greenville Hotel Spartanburg - Greenville - SC | 3.0 star rating | 110 | Spartanburg |
 | Hotel Tillman Spartanburg - Greenville - SC | 2.0 star rating | 57 | Clemson |
| Howard Johnson Anderson Clemson Area Hotel Spartanburg - Greenville - SC | 2.0 star rating | 37 | Anderson |
 | Howard Johnson Inn Spartanburg - Expo Center Hotel Spartanburg - Greenville - SC | 3.0 star rating | 50 | Spartanburg |
| Hyatt Place Greenville/Haywood Hotel Spartanburg - Greenville - SC | 3.0 star rating | 126 | Greenville |
 | Hyatt Regency Greenville Hotel Spartanburg - Greenville - SC | 3.0 star rating | 327 | Greenville |
 | La Quinta Inn & Suites Greenville Haywood Hotel Spartanburg - Greenville - SC | 3.0 star rating | 119 | Greenville |
 | MainStay Suites Pelham Road Hotel Spartanburg - Greenville - SC | 3.0 star rating | 100 | Greenville |
 | Microtel Duncan Hotel Spartanburg - Greenville - SC | 3.0 star rating | 59 | Spartanburg |
 | Microtel Inn and Suites Greenville Mall Hotel Spartanburg - Greenville - SC | 3.0 star rating | 98 | Greenville |
 | Microtel Inn & Suites Anderson/Clemson Hotel Spartanburg - Greenville - SC | 3.0 star rating | 69 | Greenville |
| Quality Inn Hotel Spartanburg - Greenville - SC | 3.0 star rating | 62 | Greer |
 | Quality Inn Hotel Spartanburg - Greenville - SC | 2.0 star rating | 81 | Greenville |