 | smartline Kyknos Beach Hotel Crete | 4.0 star rating | 133 | Malia |
 | Socrates Hotel Malia Crete | 4.0 star rating | 31 | Malia |
 | Sofia Hotel Crete | 3.0 star rating | 25 | Plakias |
| Sofia Hotel Crete | 3.0 star rating | 30 | Georgioupolis |
 | Sofia Aparthotel Hotel Crete | 3.0 star rating | 22 | Hersonissos |
 | Sofia Hotel Crete | 3.0 star rating | 69 | Heraklion City |
 | Sofia - Mythos Beach Aparthotel Hotel Crete | 3.0 star rating | 70 | Bali |
 | Sogiorka Apartments Hotel Crete | 3.0 star rating | 24 | Hersonissos |
| Solimar Aqua Marina Hotel Crete | 4.0 star rating | 104 | Chania-Platanias |
 | Solimar Dias Hotel Crete | 3.0 star rating | 76 | Rethymnon |
 | Solimar Emerald Hotel Crete | 4.0 star rating | 29 | Rethymnon |
 | Solimar Ruby Hotel Crete | 4.0 star rating | 46 | Malia |
 | Sonio Beach Hotel Crete | 3 Keys | 36 | Chania-Platanias |
 | Sorta Apartments Hotel Crete | 3.0 star rating | 7 | Agioi Apostoloi |
 | Soula Mari Hotel Crete | 3 Keys | 267 | Malia |
 | Spectacular Garden & Sea Views, At Villa Anna. Hotel Crete | Without Official Category | | Rethymnon |
 | Spilia Village Hotel Crete | 4.0 star rating | 30 | Kolymbari |
 | Spiros-Soula Family Hotel & APTS Crete | Aparthotel 1* | 25 | Aghia Pelagia |
| Spitaki Hotel Crete | 3 Keys | 2 | Plakias |
 | Splanzia Hotel Crete | 3.0 star rating | 8 | Chania City |
| Stalis Day Apartments Hotel Crete | 3.0 star rating | 24 | Stalis |
 | Star Beach Village & Waterpark Hotel Crete | 4.0 star rating | 177 | Hersonissos |
 | St. Constantin Hotel Crete | 5.0 star rating | 134 | Gouves |
| Stefania Studios Hotel Crete | 2.0 star rating | | Stalis |
 | Stefanos Village Hotel Crete | 3.0 star rating | 18 | Plakias |
 | Stelios Gardens Hotel Crete | 3.0 star rating | 25 | Malia |
 | Stelios Residence Hotel Crete | 3 Keys | 15 | Malia |
 | Stella Beach Hotel Crete | Bed And Breakfast 3* | 41 | Adele |
 | Stella Island Hotel Crete | 5.0 star rating | 234 | Analipsis |
 | Stella Katrin Hotel Crete | 2.0 star rating | | Rethymnon |
 | Stella Maria Hotel Crete | 3.0 star rating | 27 | Malia |
 | Stella Palace Hotel Crete | 4.0 star rating | 206 | Analipsis |
 | Stella Paradise Hotel Crete | 3 Keys | 12 | Hersonissos |
 | Stella Village Hotel Crete | 4.0 star rating | 200 | Analipsis |
 | Stelva Apartments Hotel Crete | 3.0 star rating | | Hersonissos |
 | Stelva Villas Hotel Crete | Aparthotel 3* | 5 | Hersonissos |
 | St. Nicolas Bay Resort Hotel & Villas Crete | 5.0 star rating | 113 | Aghios Nikolaos |
 | Stone & Green Villa Pool And Sea Views Relaxation Hotel Crete | Without Official Category | | Georgioupolis |
 | Stork Hotel Crete | 3.0 star rating | 37 | Amoudara |
 | Stylish S&K 'K' Villa 200M From The Beach Hotel Crete | Without Official Category | | Kalamaki Cre |
 | Stylish Villa Aspalathos With Amazing Sea Views! Hotel Crete | Without Official Category | | Aghia Pelagia |
 | Stylish Villa Elea With Pool And Sea View Hotel Crete | Without Official Category | | Kissamos |
 | Stylish Villa Iakinthos In Front Of The Sea Hotel Crete | Without Official Category | | Rethymnon |
| Summer Lodge Hotel Crete | Guest House | 15 | Chania-Platanias |
 | Sun Hotel Crete | 2.0 star rating | 58 | Amoudara |
| Sun And Sea Apartments Hotel Crete | 1 Star | 12 | Hersonissos |
 | Sun Beach Hotel Crete | 3.0 star rating | 200 | Georgioupolis |
| Sun City Hotel Crete | Aparthotel 2* | 40 | Chania City |
 | Sundance Apartments & Suites Hotel Crete | 4.0 star rating | 61 | Hersonissos |
 | Suneo Club Chrissi Amoudia Hotel Crete | 4.0 star rating | 224 | Anissaras |