| Baymont Inn & Suites Winston Salem Hotel Winston - Salem - NC | 3.0 star rating | | Downtown |
 | Best Western Plus Hanes Mall Hotel Winston - Salem - NC | 3.0 star rating | 130 | Downtown |
 | Comfort Inn Hotel Winston - Salem - NC | 2.0 star rating | 79 | Old Salem |
 | Comfort Inn Hotel Winston - Salem - NC | 2.0 star rating | 90 | Downtown |
 | Comfort Inn Mount Airy Hotel Winston - Salem - NC | 2.0 star rating | 52 | Old Salem |
| Comfort Inn & Suites Hotel Winston - Salem - NC | Without Official Category | | Clemmons |
 | Comfort Suites Downtown Winston Salem Hotel Winston - Salem - NC | 3.0 star rating | 80 | Downtown |
| Courtyard Winston-Salem Hanes Mall Hotel Winston - Salem - NC | 3.0 star rating | | Downtown |
| Courtyard Winston Salem/University Hotel Winston - Salem - NC | 3.0 star rating | 123 | Downtown |
 | Days Inn Jonesville Hotel Winston - Salem - NC | 3.0 star rating | 50 | Old Salem |
| Days Inn Mocksville Hotel Winston - Salem - NC | 3.0 star rating | 50 | Clemmons |
| Days Inn Mocksville NC Hotel Winston - Salem - NC | 2.0 star rating | | Clemmons |
 | Days Inn Winston Salem North Hotel Winston - Salem - NC | 3.0 star rating | 60 | Old Salem |
| Days Inn Yadkinville Hotel Winston - Salem - NC | Without Official Category | | Yadkinville |
 | DoubleTree by Hilton Winston Salem - University Hotel Winston - Salem - NC | 3.0 star rating | 150 | Downtown |
| Econo Lodge Inn & Suites Hotel Winston - Salem - NC | 3.0 star rating | 56 | Pilot Mountain |
 | Econo Lodge Kernersville Hotel Winston - Salem - NC | 3.0 star rating | 98 | Kernersville |
 | Embassy Suites Winston - Salem Hotel Winston - Salem - NC | 3.0 star rating | 146 | Downtown |
 | Green Valley Motel Hotel Winston - Salem - NC | 3.0 star rating | 60 | Old Salem |
 | Hampton Inn and Suites-Winston-Salem/University Hotel Winston - Salem - NC | 3.0 star rating | 94 | Old Salem |
 | Hampton Inn Bermuda Run/Advance Hotel Winston - Salem - NC | 3.0 star rating | 86 | Clemmons |
 | Hampton Inn Jonesville/Elkin Hotel Winston - Salem - NC | 3.0 star rating | 64 | Old Salem |
 | Hampton Inn Mount Airy Hotel Winston - Salem - NC | 3.0 star rating | 125 | Old Salem |
 | Hampton Inn & Suites Dobson Hotel Winston - Salem - NC | 3.0 star rating | 102 | Old Salem |
 | Hampton Inn Wilkesboro Hotel Winston - Salem - NC | 3.0 star rating | 75 | Old Salem |
 | Hampton Inn Winston-Salem-I-40/Hanes Mall Hotel Winston - Salem - NC | 3.0 star rating | 130 | Old Salem |
| Hawthorne Inn & Conference Center Hotel Winston - Salem - NC | 3.0 star rating | 146 | Old Salem |
 | Hilton Garden Inn Winston-Salem Hotel Winston - Salem - NC | 3.0 star rating | 112 | Downtown |
| Holiday Inn Express Kernersville Hotel Winston - Salem - NC | 3.0 star rating | 56 | Kernersville |
 | Holiday Inn Express Wilkesboro Hotel Winston - Salem - NC | 3.0 star rating | 100 | Old Salem |
 | Holiday Inn Express Winston-Salem Hotel Winston - Salem - NC | 3.0 star rating | 71 | Downtown |
| Holiday Inn Express Winston - Salem Downtown West Hotel Winston - Salem - NC | 3.0 star rating | 120 | Downtown |
| Kimpton Cardinal Hotel Winston - Salem - NC | 4.0 star rating | | Downtown |
 | Microtel Inn & Suites Winston Salem Hotel Winston - Salem - NC | 3.0 star rating | 98 | Downtown |
| Quality Inn Hotel Winston - Salem - NC | 3.0 star rating | 60 | Downtown |
 | Quality Inn and Suites Hotel Winston - Salem - NC | 3.0 star rating | 146 | Downtown |
 | Quality Inn Coliseum Hotel Winston - Salem - NC | 2.0 star rating | 134 | Downtown |
| Quality Inn & Suites Hotel Winston - Salem - NC | 4.0 star rating | | Pilot Mountain |
| Quality Inn University Hotel Winston - Salem - NC | 3.0 star rating | 113 | Old Salem |
| Residence Inn Winston-Salem Hanes Mall Hotel Winston - Salem - NC | 3.0 star rating | | Downtown |
| Residence Inn Winston-Salem University Area Hotel Winston - Salem - NC | 3.0 star rating | 88 | Downtown |
| Rodeway Inn Hotel Winston - Salem - NC | Without Official Category | | Downtown |
 | Sleep Inn Hotel Winston - Salem - NC | 3.0 star rating | 104 | Kernersville |
 | Sleep Inn Hanes Mall Hotel Winston - Salem - NC | 2.0 star rating | 73 | Downtown |
| SpringHill Suites Winston-Salem Hanes Mall Hotel Winston - Salem - NC | 3.0 star rating | 95 | Downtown |
| Super 8 Clemmons/Winston-Salem Area Hotel Winston - Salem - NC | 2.0 star rating | 56 | Clemmons |
 | WINSTON-SALEM HOTEL AND SPA Hotel Winston - Salem - NC | 3.0 star rating | 150 | Downtown |