| Asturias Hotel Santa Cruz | 4.0 star rating | 64 | Centro |
 | Biocentro Güembe Hotel Santa Cruz | 4.0 star rating | 12 | Equipetrol |
 | Buganvillas Hotel Santa Cruz | 5.0 star rating | 117 | Centro |
 | Camino Real Hotel Santa Cruz | 5.0 star rating | 121 | Equipetrol |
 | Caparuch Hotel Santa Cruz | 4.0 star rating | 62 | Centro |
 | Casa de Bourbon Hotel Santa Cruz | 4.0 star rating | 21 | Equipetrol |
 | Casa Internacional Los Aventureros Hotel Santa Cruz | 3.0 star rating | 8 | Centro |
 | Continental Park Hotel Santa Cruz | 4.0 star rating | 56 | Centro |
| Cortez LTDA Hotel Santa Cruz | 5.0 star rating | 183 | Equipetrol |
 | Gran Hotel Santa Cruz | Superior 4* | 100 | Centro |
 | Hampton By Hilton Santa Cruz Hotel | 5.0 star rating | 72 | Equipetrol |
| Hampton Inn Santa Cruz/Equipetrol Hotel | 3.0 star rating | 72 | Centro |
| Hotel Libertador Simon Bolivar Santa Cruz | 3.0 star rating | 48 | Centro |
 | Hotel Los Aventureros Santa Cruz | 3.0 star rating | | Centro |
 | Hotel Senses Centro Santa Cruz | 5.0 star rating | 54 | Centro |
 | Hotel Terranova Suites Santa Cruz | 5.0 star rating | 82 | Aeropuerto Viru Viru |
 | Hotel Torre Santa Cruz | 4.0 star rating | 35 | Trompillo |
| Kusinitana Misional Hotel Santa Cruz | 3.0 star rating | 32 | Centro |
 | Las Americas Hotel Santa Cruz | 3.0 star rating | 62 | Centro |
 | Las Palmas Hotel Santa Cruz | 4.0 star rating | 38 | Trompillo |
 | Los Cedros Eco Resort Santa Cruz | 5.0 star rating | 60 | La Guardia |
 | Los Tajibos Hotel Santa Cruz | 5.0 star rating | 184 | Equipetrol |
| Los Trotamundos Hotel Santa Cruz | 2.0 star rating | 8 | Centro |
 | LP Equipetrol Hotel Santa Cruz | 4.0 star rating | 72 | Centro |
 | LP Santa Cruz Centro Hotel | 3.0 star rating | 40 | Centro |
 | Mai Suites Apart Hotel Santa Cruz | 4.0 star rating | 18 | Centro |
 | Paulistania Casa Blanca Hotel Santa Cruz | 5.0 star rating | 168 | Equipetrol |
| Prince Hotel Santa Cruz | 4.0 star rating | 30 | Centro |
 | Radisson Hotel Santa Cruz | 5.0 star rating | 210 | Centro |
 | Rio Selva Resort-Santa Cruz | 5.0 star rating | 69 | Warnes |
 | Royal Lodge Hotel Santa Cruz | 4.0 star rating | 51 | Equipetrol |
 | Senses hotel Boutique Hotel Santa Cruz | 5.0 star rating | 52 | Centro |
 | Senses Premium Residence Hotel Santa Cruz | 4.0 star rating | 14 | Equipetrol |
 | Sun Hotel Santa Cruz | 5.0 star rating | 54 | Aeropuerto Viru Viru |
 | Toborochi Suites Hotel Santa Cruz | 5.0 star rating | 35 | Equipetrol |
 | Yotau All Suites Hotel Santa Cruz | 5.0 star rating | 93 | Equipetrol |