| Prekas Hotel Santorini | 3.0 star rating | | Imerovigli |
 | Proteas Hotel Santorini | 1 Star | 15 | Kamari |
 | Pyrgos Kastelli Villas Hotel Santorini | Villa | | Pyrgos |
 | Red Cliff Villa Hotel Santorini | 4.0 star rating | 3 | Akrotiri |
 | Regina Mare Hotel Santorini | 4.0 star rating | 20 | Imerovigli |
 | Remezzo Apartments Hotel Santorini | 3 Keys | 12 | Imerovigli |
 | Rena Hotel Santorini | 2.0 star rating | 27 | Perissa-Perivolos |
 | Rena Suites Hotel Santorini | 3.0 star rating | 17 | Fira |
 | Residence Suites Hotel Santorini | 3.0 star rating | 21 | Oia |
 | Rivari Santorini Hotel | 3.0 star rating | 63 | Kamari |
| RK Beach hotel Hotel Santorini | 4.0 star rating | 38 | Kamari |
 | Rocabella Deluxe Suites & SPA Hotel Santorini | 4.0 star rating | 43 | Imerovigli |
| Rose Bay Hotel Santorini | 4.0 star rating | 55 | Kamari |
 | Roula Villa Hotel Santorini | 3.0 star rating | 28 | Perissa-Perivolos |
 | Salty Beach Hotel Santorini | 3.0 star rating | 12 | Perissa-Perivolos |
 | San Antonio Hotel Santorini | 5.0 star rating | 26 | Imerovigli |
| Santa Barbara Hotel Santorini | 3.0 star rating | 12 | Perissa-Perivolos |
 | Santa Elena Hotel Santorini | 3.0 star rating | 18 | Kamari |
| Santa Irini Hotel Santorini | 1 Star | 16 | Kamari |
 | Santellini Hotel Santorini | 3.0 star rating | 26 | Kamari |
 | Santo Maris Oia, Luxury Suites & Spa Hotel Santorini | 5.0 star rating | 44 | Oia |
 | Santo Miramare Resort Santorini | 4.0 star rating | 117 | Perissa-Perivolos |
| Santorini Hotel | 1 Star | 24 | Fira |
 | Santorini Crystal Blue Hotel | 4.0 star rating | 16 | Kamari |
 | Santorini Heritage Villas & Mansions Hotel | 3 Keys | 2 | Megalochori |
 | Santorini Image Hotel | 4.0 star rating | 60 | Messaria |
 | Santorini Palace Hotel | 4.0 star rating | 106 | Firostefani |
 | Santorini Princess Luxury Spa Hotel | Aparthotel 5* | 22 | Imerovigli |
 | Santorini Princess Presidential Suites Hotel | 5.0 star rating | 4 | Megalochori |
| Santorini Reflexions Sea Hotel | Pending Category | 11 | Firostefani |
 | Santorini Reflexions Volcano Hotel | 3.0 star rating | 7 | Fira |
 | Santorini Royal Suites Hotel | 4.0 star rating | 8 | Fira |
 | Santorini's Balcony Art Houses Hotel | 4.0 star rating | 12 | Imerovigli |
 | SANTORINI SECRET PREMIUM Hotel Santorini | 4 Keys | 5 | Oia |
 | Santorini Secret Suites & Spa Hotel | 5.0 star rating | 19 | Fira |
 | Santorini Villas Hotel | 3.0 star rating | | Messaria |
| Sany Small & Frenly Hotel Santorini | 3.0 star rating | | Perissa-Perivolos |
 | Scorpios Beach Hotel Santorini | Aparthotel 4* | 23 | Aghios Paraskevi-Monolithos |
 | Sea And Sky Villas Hotel Santorini | Villa | 1 | Imerovigli |
 | Sea Of Aegeon Hotel Santorini | 1 Star | 24 | Fira |
 | Sea & Sand Villas Hotel Santorini | Villa | 1 | Aghios Paraskevi-Monolithos |
| Sea Sound Hotel Santorini | 4.0 star rating | 60 | Perissa-Perivolos |
 | Sea Sound - White Katikies Hotel Santorini | 5.0 star rating | 13 | Perissa-Perivolos |
 | Sea View Hotel Santorini | 3.0 star rating | 19 | Perissa-Perivolos |
 | SECRET LEGEND SUITES Hotel Santorini | 5.0 star rating | 6 | Oia |
 | Selini Hotel Santorini | 3.0 star rating | 29 | Kamari |
| Sellada Apts Hotel Santorini | Aparthotel 3* | 7 | Kamari |
 | Sellada Beach Hotel Santorini | 4.0 star rating | 295 | Perissa-Perivolos |
 | Semeli Cave House Hotel Santorini | 4.0 star rating | 3 | Pyrgos |
| Senses Boutique Hotel Santorini | 4.0 star rating | 5 | Imerovigli |