 | En Plo Boutique Suites Hotel Santorini | 3.0 star rating | 7 | Oia |
 | Epavlis Hotel Santorini | 4.0 star rating | 45 | Kamari |
| Epavlis Hotel Santorini | 3.0 star rating | | Kamari |
 | Erato Apartments Hotel Santorini | 4 Keys | 21 | Firostefani |
| Erofili Villa Hotel Santorini | 4.0 star rating | 3 | Fira |
 | Ersi Villas Hotel Santorini | 3 Keys | 16 | Firostefani |
| Esperas Houses Apartments Hotel Santorini | Aparthotel 4* | 21 | Oia |
 | Ether Studios Hotel Santorini | 3.0 star rating | 4 | Oia |
 | Evgenia Villas & Suites Hotel Santorini | 3.0 star rating | 14 | Fira |
 | Exclusive Plan Suites Hotel Santorini | 4.0 star rating | 6 | Firostefani |
| Family Vassalos Hotel Santorini | 3 Keys | 30 | Perissa-Perivolos |
 | Fanari Villas Hotel Santorini | 4.0 star rating | 16 | Oia |
| Fanari Vista Suites Hotel Santorini | Pending Category | | Fira |
| Fenix Collection Hotel Santorini | 4 Keys | 33 | Perissa-Perivolos |
 | Filotera Suites Hotel Santorini | 5.0 star rating | 8 | Oia |
 | Filotimo Cave Houses Hotel Santorini | 2 Keys | 3 | Pyrgos |
 | Finikas Hotel Santorini | 2.0 star rating | 11 | Kamari |
 | Finikia Memories (ex Finikia's Place) Hotel Santorini | 3.0 star rating | 24 | Oia |
| Fira Blue Horizon Hotel Santorini | 3.0 star rating | 15 | Fira |
 | Fomithea Hotel Santorini | 3.0 star rating | 33 | Kamari |
 | Gaia Hotel Santorini | 4.0 star rating | 48 | Perissa-Perivolos |
| Galatia Villas Hotel Santorini | Rural Hotel | 10 | Fira |
 | Galaxy Suites Hotel Santorini | 3.0 star rating | 14 | Imerovigli |
 | Gardenia Hotel Santorini | 3.0 star rating | 16 | Perissa-Perivolos |
| Gizis Exclusive Apartments Hotel Santorini | 3.0 star rating | | Imerovigli |
 | Gizis Hotel Santorini | 4 Keys | 15 | Imerovigli |
 | Glaros Hotel Santorini | 3.0 star rating | 26 | Kamari |
 | Gold Suites Hotel Santorini | 4.0 star rating | 14 | Imerovigli |
| Gorgona Villas Hotel Santorini | 4.0 star rating | | Imerovigli |
 | Gorgona Villas Hotel Santorini | 4 Keys | 14 | Imerovigli |
 | Goulielmos Hotel Santorini | 3.0 star rating | 27 | Akrotiri |
 | Grace Santorini Hotel | 5.0 star rating | 22 | Imerovigli |
| Heliophos Boutique Hotel Santorini | 3.0 star rating | | Oia |
 | Heliotopos Hotel Santorini | 4.0 star rating | 10 | Imerovigli |
 | Hellas Hotel Santorini | 2.0 star rating | 50 | Fira |
 | Hermes Hotel Santorini | 4.0 star rating | 44 | Kamari |
 | Homeric Poems Hotel Santorini | 4.0 star rating | 20 | Firostefani |
| HOMERIC POEMS 2 Hotel Santorini | 4.0 star rating | | Firostefani |
 | Honeymoon Petra Villas Hotel Santorini | Aparthotel 4* | 26 | Imerovigli |
| Horizon Hotel Santorini | 3.0 star rating | 17 | Kamari |
| Hotel Mylos Santorini | 2.0 star rating | 8 | Fira |
 | Hotel Porto Carra Santorini | 2.0 star rating | 11 | Fira |
 | Icons Hotel Santorini | 5.0 star rating | 23 | Imerovigli |
 | Ikaros Hotel Santorini | 2.0 star rating | 20 | Fira-Karterados |
 | Ikies Traditional Houses Hotel Santorini | 3 Keys | 11 | Oia |
 | Iliada Hotel Santorini | 2.0 star rating | 25 | Perissa-Perivolos |
| Ilioperato Imerovigli Hotel Santorini | 4 Keys | 4 | Imerovigli |
 | Iliovasilema Suites Hotel Santorini | 4.0 star rating | 19 | Imerovigli |
 | Imperial Med Hotel Santorini | 4.0 star rating | 47 | Aghios Paraskevi-Monolithos |
 | Impressive One Hotel Santorini | 4 Keys | 15 | Kamari |