 | Carpe Diem Exclusive Boutique Resort Santorini | 4.0 star rating | 10 | Pyrgos |
 | Casa Bianca Hotel Santorini | 3.0 star rating | 9 | Imerovigli |
 | Casa Florina Hotel Santorini | 3 Keys | 7 | Imerovigli |
 | Casa Santantonio Hotel Santorini | 4.0 star rating | 3 | Kamari |
 | Castro Hotel Santorini | 3.0 star rating | 18 | Kamari |
 | Cavo Bianco Hotel Santorini | 5.0 star rating | 43 | Kamari |
 | Cavo Santo Hotel Santorini | 4.0 star rating | 30 | Akrotiri |
 | Cavo Tagoo Santorini Hotel | 5.0 star rating | 13 | Imerovigli |
 | Cavo Ventus Hotel Santorini | 5.0 star rating | 4 | Akrotiri |
 | Celestia Grand Hotel Santorini | 5.0 star rating | 6 | Fira |
 | Central Fira Hotel Santorini | 3 Keys | 9 | Fira |
| Central Pyrgos Hotel Santorini | 4 Keys | 9 | Pyrgos |
 | Charisma Suites Hotel Santorini | 5.0 star rating | 8 | Oia |
 | Charlina Hotel Santorini | 1 Star | 10 | Perissa-Perivolos |
| Chez Sophie Rooms And Suites Hotel Santorini | Pending Category | | Kamari |
 | Chroma Suites Hotel Santorini | 3.0 star rating | 3 | Oia |
 | Chromata Up Style Hotel Santorini | 5.0 star rating | 26 | Imerovigli |
 | Cliffside Suites Hotel Santorini | 4.0 star rating | 24 | Firostefani |
 | Cocoon Suites Hotel Santorini | 5.0 star rating | 8 | Imerovigli |
| Cori Rigas Suites Hotel Santorini | 4.0 star rating | 12 | Fira |
 | Cosmopolitan Suites Hotel Santorini | 4.0 star rating | 10 | Fira |
 | Crown Suites Hotel Santorini | 4.0 star rating | 35 | Kamari |
 | Csky Hotel Santorini | 5.0 star rating | 8 | Imerovigli |
 | Cyclades Hotel Santorini | 2.0 star rating | 25 | Fira-Karterados |
 | Daedalus Hotel Santorini | 4.0 star rating | 45 | Fira |
 | Danae Villas Hotel Santorini | Pending Category | | Fira |
 | Dana Villas Hotel Santorini | 3.0 star rating | 30 | Firostefani |
 | Daydream Luxury Suites Hotel Santorini | 5.0 star rating | 4 | Fira |
 | Delfini Villas Hotel Santorini | 3.0 star rating | 10 | Oia |
 | De Sol Resort Santorini | 5.0 star rating | 45 | Fira |
 | Dilino Hotel Santorini | 2.0 star rating | 12 | Kamari |
 | Dimitris Studios Hotel Santorini | 3.0 star rating | 19 | Kamari |
| Dimitris Villas Hotel Santorini | 3 Keys | 19 | Kamari |
 | Dolphins Hotel Santorini | 3.0 star rating | 20 | Kamari |
| Domes Resort Santorini | 4.0 star rating | | Imerovigli |
 | Dreaming View Suites Hotel Santorini | 3 Keys | 4 | Imerovigli |
 | Dreams Luxury Suites Hotel Santorini | 5.0 star rating | 6 | Imerovigli |
 | Drossos Hotel Santorini | 4.0 star rating | 26 | Perissa-Perivolos |
| Earino Suites Villas Hotel Santorini | 3 Keys | 5 | Akrotiri |
 | Efterpi Villas Hotel Santorini | 2.0 star rating | 10 | Firostefani |
 | Ekati Studios & Apartments Hotel Santorini | 3.0 star rating | 12 | Kamari |
| Elea Resort Santorini | 4.0 star rating | 17 | Oia |
 | El Greco Hotel Santorini | 4.0 star rating | 149 | Fira |
 | El Greco Palace & SPA Hotel Santorini | 5.0 star rating | | Fira |
| El Greco Resort Hotel Santorini | 4.0 star rating | | Messaria |
 | Elite Luxury Suites Hotel Santorini | 4.0 star rating | 4 | Oia |
 | Elixir Studios Hotel Santorini | 3.0 star rating | 14 | Kamari |
 | El Mar Villas Hotel Santorini | 3 Keys | 15 | Kamari |
 | Emmanuela Studios Hotel Santorini | 2 Keys | 12 | Fira-Karterados |
 | Enjoy Villas Hotel Santorini | 3.0 star rating | 13 | Kamari |