 | Baymont Inn & Suites Manning Hotel Orangeburg - SC | 3.0 star rating | 51 | Orangeburg |
| Baymont Inn & Suites Orangeburg Hotel Orangeburg - SC | 2.0 star rating | | Orangeburg |
 | Baymont Inn & Suites Orangeburg North Hotel Orangeburg - SC | 2.0 star rating | 172 | Orangeburg |
 | Best Western Plus Santee Inn Hotel Orangeburg - SC | 3.0 star rating | 100 | Santee Area |
| Comfort Inn & Suites Hotel Orangeburg - SC | 3.0 star rating | 61 | Santee Area |
| Comfort Inn & Suites Hotel Orangeburg - SC | 3.0 star rating | 69 | Orangeburg |
 | Days Inn Manning Hotel Orangeburg - SC | 3.0 star rating | 57 | Orangeburg |
| Days Inn Orangeburg Hotel Orangeburg - SC | 2.0 star rating | 76 | Orangeburg |
| Days Inn Orangeburg South Hotel Orangeburg - SC | 2.0 star rating | 97 | Orangeburg |
| Econo Lodge Hotel Orangeburg - SC | 2.0 star rating | 37 | Orangeburg |
| Econo Lodge Inn & Suites Hotel Orangeburg - SC | Without Official Category | | Orangeburg |
| Fairfield Inn Orangeburg Hotel Orangeburg - SC | 3.0 star rating | 64 | Orangeburg |
 | Hampton Inn and Suites Orangeburg, SC Hotel Orangeburg - SC | 2.0 star rating | 90 | Orangeburg |
 | Hampton Inn Manning Hotel Orangeburg - SC | 3.0 star rating | 73 | Orangeburg |
 | Hampton Inn Santee-I-95 Hotel Orangeburg - SC | 3.0 star rating | 81 | Orangeburg |
| Holiday Inn Express and Suites Orangeburg Hotel Orangeburg - SC | 3.0 star rating | | Orangeburg |
| Holiday Inn Santee Hotel Orangeburg - SC | 3.0 star rating | | Orangeburg |
 | Howard Johnson Inn Santee Hotel Orangeburg - SC | 3.0 star rating | 60 | Santee Area |
| Knights Inn St George Hotel Orangeburg - SC | 2.0 star rating | 54 | Orangeburg |
 | Lake Marion Resort and Marina Orangeburg - SC | 3.0 star rating | | Orangeburg |
| Quality Inn & Suites Hotel Orangeburg - SC | 3.0 star rating | 153 | Santee Area |
 | Ramada of Manning Hotel Orangeburg - SC | 3.0 star rating | 44 | Orangeburg |
| Rodeway Inn Hotel Orangeburg - SC | 2.0 star rating | 34 | Orangeburg |
| Rodeway Inn & Suites Hotel Orangeburg - SC | 3.0 star rating | 90 | Orangeburg |
| Sleep Inn Hotel Orangeburg - SC | 3.0 star rating | 69 | Orangeburg |
| Super 8 Orangeburg Hotel Orangeburg - SC | 2.0 star rating | | Orangeburg |
| Super 8 Orangeburg Near I-26 Hotel Orangeburg - SC | Without Official Category | | Orangeburg |
| Super 8 Santee Hotel Orangeburg - SC | 3.0 star rating | 41 | Orangeburg |
 | Wyndham Vacation Resorts Lake Marion Orangeburg - SC | 4.0 star rating | 70 | Santee Area |