Santee Area Hotels
| Hotel Name | Star Rating | Number of Rooms | Location | |
|---|---|---|---|---|
 | Best Western Plus Santee Inn Hotel Orangeburg - SC | 3.0 star rating | 100 | Santee Area |
| Comfort Inn & Suites Hotel Orangeburg - SC | 3.0 star rating | 61 | Santee Area | |
 | Howard Johnson Inn Santee Hotel Orangeburg - SC | 3.0 star rating | 60 | Santee Area |
| Quality Inn & Suites Hotel Orangeburg - SC | 3.0 star rating | 153 | Santee Area | |
 | Wyndham Vacation Resorts Lake Marion Orangeburg - SC | 4.0 star rating | 70 | Santee Area |
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