 | Baymont Inn & Suites Salem Roanoke Area Hotel Roanoke - VA | 2.0 star rating | 115 | Salem |
 | Best Western Inn at Valley View Hotel Roanoke - VA | 3.0 star rating | 85 | Airport |
 | Cambria Suites Roanoke Hotel Roanoke - VA | 3.0 star rating | 127 | Salem |
| Clay Corner Inn Hotel Roanoke - VA | 3.0 star rating | 8 | Roanoke Area |
 | Comfort Inn Hotel Roanoke - VA | 3.0 star rating | 80 | Roanoke Area |
| Comfort Inn Hotel Roanoke - VA | 3.0 star rating | 75 | Downtown |
| Comfort Inn Airport Hotel Roanoke - VA | 3.0 star rating | 96 | Airport |
 | Comfort Inn Smith Mt. Lake Hotel Roanoke - VA | 2.0 star rating | 61 | Rocky Mount |
 | Comfort Inn & Suites Hotel Roanoke - VA | 3.0 star rating | 72 | Roanoke Area |
 | Comfort Suites Hotel Roanoke - VA | 3.0 star rating | 72 | Salem |
 | Comfort Suites Inn at Ridgewood Farm Hotel Roanoke - VA | 3.0 star rating | 78 | Salem |
 | Country Inn & Suites - Roanoke Hotel Roanoke - VA | 3.0 star rating | 77 | Downtown |
 | Days Inn Bedford Hotel Roanoke - VA | 3.0 star rating | 75 | Troutville |
 | Days Inn Blacksburg Conference Center Hotel Roanoke - VA | 3.0 star rating | 98 | Roanoke Area |
 | Days Inn Christiansburg Hotel Roanoke - VA | 3.0 star rating | 116 | Downtown |
 | Days Inn Civic Center Hotel Roanoke - VA | 3.0 star rating | 199 | Roanoke Area |
 | Days Inn Roanoke Near I-81 Hotel Roanoke - VA | 3.0 star rating | 123 | Roanoke Area |
 | Days Inn Salem Hotel Roanoke - VA | 3.0 star rating | 70 | Salem |
 | Econo Lodge Hotel Roanoke - VA | 3.0 star rating | 72 | Christiansburg |
 | Econo Lodge Civic Center Hotel Roanoke - VA | 1 Star And A Half | 46 | Rocky Mount |
 | Hampton Inn and Suites Roanoke-Downtown, VA Hotel Roanoke - VA | 2.0 star rating | 127 | Downtown |
 | Hampton Inn Christiansburg/Blacksburg Hotel Roanoke - VA | 3.0 star rating | 119 | Roanoke Area |
 | Hampton Inn Gretna/Altavista/Chatham Hotel Roanoke - VA | 3.0 star rating | 80 | Rocky Mount |
 | Hampton Inn Martinsville Hotel Roanoke - VA | 3.0 star rating | 68 | Rocky Mount |
 | Hampton Inn Roanoke/Hollins - I-81 Hotel Roanoke - VA | 3.0 star rating | 99 | Roanoke Area |
 | Hampton Inn Roanoke/Salem Hotel Roanoke - VA | 3.0 star rating | 113 | Salem |
| Hampton Inn Salem/Roanoke Area, VA Hotel Roanoke - VA | 2.0 star rating | 89 | Salem |
| Hampton Inn & Suites Roanoke Airport Hotel Roanoke - VA | 3.0 star rating | 130 | Airport |
 | Hilton Garden Inn Blacksburg Hotel Roanoke - VA | 3.0 star rating | 137 | Roanoke Area |
 | Hilton Garden Inn Roanoke, VA Hotel Roanoke - VA | 3.0 star rating | 117 | Roanoke Area |
| Holiday Inn Christiansburg Blacksburg Hotel Roanoke - VA | 3.0 star rating | 93 | Roanoke Area |
| Holiday Inn Express and Suites Christiansburg Hotel Roanoke - VA | 3.0 star rating | | Christiansburg |
| Holiday Inn Express and Suites Rocky Mount Smith M Hotel Roanoke - VA | 3.0 star rating | | Rocky Mount |
| Holiday Inn Express Dublin Hotel Roanoke - VA | 3.0 star rating | 61 | Dublin |
| Holiday Inn Express Hotel & Suites Salem Roanoke - VA | 3.0 star rating | 75 | Salem |
| Holiday Inn Express Roanoke - Civic Center Hotel Roanoke - VA | 3.0 star rating | 92 | Rocky Mount |
| Holiday Inn Express Troutville - Roanoke North Hotel Roanoke - VA | 3.0 star rating | 85 | Troutville |
 | Holiday Inn Exp & Suites Blacksburg â Univ Area Hotel Roanoke - VA | 3.0 star rating | 94 | Blacksburg |
| Holiday Inn Roanoke - Tanglewood Rt 419 & I581 Hotel Roanoke - VA | 3.0 star rating | 196 | Downtown |
| Holiday Inn Roanoke Valley View Hotel Roanoke - VA | 3.0 star rating | | Airport |
| Home2 Suites Roanoke, VA Hotel Roanoke - VA | 3.0 star rating | | Airport |
| Homewood Suites by Hilton Christiansburg, VA Hotel Roanoke - VA | 3.0 star rating | 82 | Christiansburg |
 | Howard Johnson Inn And Conference Center Salem Hotel Roanoke - VA | 3.0 star rating | 102 | Salem |
| Howard Johnson Inn Daleville/Roanoke North Hotel Roanoke - VA | 2.0 star rating | | Daleville |
 | Howard Johnson Inn Roanoke/Airport Hotel Roanoke - VA | 3.0 star rating | | Airport |
| Hyatt Place Roanoke Airport/Valley View Mall Hotel Roanoke - VA | 3.0 star rating | | Airport |
 | Knights Inn Collinsville Hotel Roanoke - VA | 3.0 star rating | 40 | Collinsville |
| Knights Inn Roanoke Hotel Roanoke - VA | 3.0 star rating | 118 | Downtown |
 | MainStay Suites Airport Hotel Roanoke - VA | 3.0 star rating | 77 | Airport |
 | Microtel Inn & Suites Christiansburg/Blacksburg Hotel Roanoke - VA | 3.0 star rating | 86 | Roanoke Area |