 | Roseberry Studios Hotel Rhodes | 2 Keys | 15 | Faliraki |
 | Rose Hotel Rhodes | 2.0 star rating | 38 | Faliraki |
| Rosmari Htl Hotel Rhodes | 2.0 star rating | 18 | Arhangelos |
 | Royal Apart Hotel Rhodes | 2.0 star rating | 39 | Rhodes Town |
 | Sabina Hotel Rhodes | 3.0 star rating | 71 | Theologos |
 | Saint Amon Hotel Rhodes | 2 Keys | 16 | Faliraki |
| Saint Artemios Boutique Hotel Rhodes | 4.0 star rating | | Rhodes Town |
 | Saint Konstantin Hotel Rhodes | 4 Keys | 24 | Stegna |
 | Saint Nikolis Hotel Rhodes | 4.0 star rating | 16 | Rhodes Town |
 | Santa Helena Hotel Rhodes | 3.0 star rating | 22 | Ialyssos |
 | Saronis Hotel Rhodes | 2.0 star rating | 29 | Rhodes Town |
 | Sarris Studios Hotel Rhodes | 3.0 star rating | 14 | Lindos |
 | Savoy Hotel Rhodes | 2.0 star rating | 46 | Rhodes Town |
 | Sea Harmony Hotel Rhodes | 3.0 star rating | 9 | Kalathos |
| Sea View Studios Hotel Rhodes | 3.0 star rating | | Theologos |
| Secret Garden Villa Hotel Rhodes | 4.0 star rating | 4 | Ialyssos |
 | Semina Hotel Rhodes | 1 Star | 34 | Arhangelos |
 | Semiramis Hotel Rhodes | 4.0 star rating | 180 | Rhodes Town |
 | SENTIDO Apollo Blue Hotel Rhodes | 5.0 star rating | 134 | Faliraki |
 | Sentido Ixian Grand Hotel Rhodes | 5.0 star rating | 280 | Ixia |
 | Sentido Lindos Bay Resort & SPA Rhodes | 4.0 star rating | 52 | Lindos |
 | Sevastos Studios Hotel Rhodes | 2.0 star rating | 30 | Faliraki |
 | Seven Springs Artemis Villas Hotel Rhodes | 4.0 star rating | 1 | Afandou |
 | Seven Spring Villas Hotel Rhodes | 4.0 star rating | 3 | Kolymbia |
 | Sheraton Rhodes Resort | 5.0 star rating | 401 | Ixia |
 | Sirene beach Hotel Rhodes | 4.0 star rating | 110 | Ixia |
 | Sivila Hotel Rhodes | 3.0 star rating | 59 | Afandou |
 | Smarline Cosmopolitan Hotel Rhodes | 4.0 star rating | 377 | Ixia |
 | Sofias Blue Hotel Rhodes | 3 Keys | 7 | Faliraki |
 | Solemar APT Hotel Rhodes | 3.0 star rating | 102 | Ixia |
| Solemar Hotel Rhodes | 3.0 star rating | 102 | Ixia |
 | Sotirakis Studios Hotel Rhodes | 3.0 star rating | | Faliraki |
 | Sperveri Boutique Hotel Rhodes | 4.0 star rating | 7 | Rhodes Town |
 | Sperveri Enalio Villas Hotel Rhodes | Villa | 3 | Kolymbia |
| Spilia Bay Villas Hotel Rhodes | 5 Keys | 3 | Lindos |
 | Spirit of the Knights Hotel Rhodes | 4.0 star rating | 6 | Rhodes Town |
 | Stamos Hotel Rhodes | 3.0 star rating | | Faliraki |
| Stamos Studios Hotel Rhodes | 1 Star | 48 | Faliraki |
 | Stavris Studios Hotel Rhodes | 2 Keys | 23 | Faliraki |
 | Stavros Melathron Hotel Rhodes | 2 Keys | 20 | Kallithea |
 | Stegna Mare Hotel Rhodes | 3 Keys | 12 | Stegna |
 | Stegna Star Hotel Rhodes | 3.0 star rating | 20 | Stegna |
| Stella Hotel Rhodes | 3.0 star rating | 97 | Lindos |
 | Stergios Villa Hotel Rhodes | 3.0 star rating | 3 | Kolymbia |
| Stone Garden Apartments Hotel Rhodes | 3.0 star rating | | Faliraki |
 | St.Paul's Bay Studios Hotel Rhodes | 3.0 star rating | 5 | Lindos |
 | Summer Breeze Hotel Rhodes | 2.0 star rating | 25 | Gennadi |
| Summer Days Hotel Rhodes | Apartment 2nd Category | | Faliraki |
 | Summer Dream Hotel Rhodes | 3.0 star rating | 79 | Tholos |
| Summer Memories Aparthotel Hotel Rhodes | 2.0 star rating | 37 | Pefkos |