| 21C Museum Hotel Durham Raleigh/Durham - NC | 5.0 star rating | | Durham |
 | Cambria hotel & suites DurhamDuke University Medi Hotel Raleigh/Durham - NC | 3.0 star rating | | Durham |
 | Candlewood Suites Durham-RTP Hotel Raleigh/Durham - NC | 3.0 star rating | | Durham |
 | Comfort Inn Medical Park Hotel Raleigh/Durham - NC | 2.0 star rating | 136 | Durham |
 | Comfort Inn Research Triangle Park Hotel Raleigh/Durham - NC | 3.0 star rating | 92 | Durham |
 | Comfort Inn University Hotel Raleigh/Durham - NC | 3.0 star rating | 136 | Durham |
 | Comfort Suites (Durham) Hotel Raleigh/Durham - NC | 3.0 star rating | 125 | Durham |
 | Courtyard by Marriott Durham near Duke University/ Hotel Raleigh/Durham - NC | 4.0 star rating | 146 | Durham |
| Courtyard Durham Research Triangle Park Hotel Raleigh/Durham - NC | 3.0 star rating | 123 | Durham |
| Crossland Economy Studios - Durham - Research Tria Hotel Raleigh/Durham - NC | 3.0 star rating | | Durham |
 | Days Inn Hotel Raleigh/Durham - NC | 3.0 star rating | 100 | Durham |
 | Doubletree Guest Suites Hotel Raleigh/Durham - NC | 3.0 star rating | 203 | Durham |
| Durham Marriott City Center Hotel Raleigh/Durham - NC | 3.0 star rating | 190 | Durham |
| Econo Lodge Research Triangle Park Hotel Raleigh/Durham - NC | 3.0 star rating | 86 | Durham |
 | Embassy Suites Raleigh Durham Airport Brier Hotel Raleigh/Durham - NC | 3.0 star rating | 173 | Durham |
 | Hampton Inn and Suites Durham-North I-85 Hotel Raleigh/Durham - NC | 4.0 star rating | 137 | Durham |
 | Hilton Durham near Duke University Hotel Raleigh/Durham - NC | 4.0 star rating | 195 | Durham |
| Hilton Garden Inn Durham/University Medical Center Hotel Raleigh/Durham - NC | 3.0 star rating | 128 | Durham |
| Holiday Inn Express and Suites Research Triangle P Hotel Raleigh/Durham - NC | 3.0 star rating | | Durham |
| Holiday Inn Express Durham Hotel Raleigh/Durham - NC | 3.0 star rating | 79 | Durham |
| Home2 Suites by Hilton Durham, NC Hotel Raleigh/Durham - NC | 3.0 star rating | 103 | Durham |
| Millennium Durham Hotel Raleigh/Durham - NC | 3.0 star rating | | Durham |
| Millennium Durham Hotel Raleigh/Durham - NC | 3.0 star rating | 313 | Durham |
 | Quality Inn & Suites (Durham) Hotel Raleigh/Durham - NC | 3.0 star rating | 114 | Durham |
 | Red Roof Inn Chapel Hill - UNC Hotel Raleigh/Durham - NC | 2.0 star rating | | Durham |
 | Red Roof Inn Durham - Duke University Medical Ctr Hotel Raleigh/Durham - NC | 2.0 star rating | | Durham |
 | Red Roof Inn Durham - Triangle Park Hotel Raleigh/Durham - NC | 2.0 star rating | | Durham |
| Residence Inn by Marriott Durham Duke University M Hotel Raleigh/Durham - NC | 4.0 star rating | 145 | Durham |
| Residence Inn Durham Research Triangle Park Hotel Raleigh/Durham - NC | 3.0 star rating | 122 | Durham |
 | Sheraton Imperial Hotel & Convention Center Raleigh/Durham - NC | 3.0 star rating | 331 | Durham |
 | Sleep Inn (Durham) Hotel Raleigh/Durham - NC | 2.0 star rating | 73 | Durham |
| SpringHill Suites Durham Chapel Hill Hotel Raleigh/Durham - NC | 3.0 star rating | 130 | Durham |
| SpringHill Suites Raleigh-Durham Airport Hotel Raleigh/Durham - NC | 3.0 star rating | 120 | Durham |
| Staybridge Suites Durham-Chapel Hill-RTP Hotel Raleigh/Durham - NC | 3.0 star rating | 88 | Durham |
| Super 8 Motel - Durham Hotel Raleigh/Durham - NC | 3.0 star rating | 48 | Durham |
| University Inn at Duke Hospital Hotel Raleigh/Durham - NC | 3.0 star rating | | Durham |
 | Wingate By Wyndham Raleigh Durham Airport Hotel Raleigh/Durham - NC | 3.0 star rating | 85 | Durham |