| Americas Best Inns-Portsmouth Hotel Portsmouth - NH | 3.0 star rating | | Downtown |
 | Best Western Plus Portsmouth Hotel & Suites Portsmouth - NH | 3.0 star rating | 169 | Downtown |
 | Comfort Inn Hotel Portsmouth - NH | 4.0 star rating | 121 | Downtown |
 | Comfort Inn & Suites Hotel Portsmouth - NH | 3.0 star rating | 96 | Dover |
 | Courtyard by Marriott Portsmouth Hotel Portsmouth - NH | 2.0 star rating | 133 | Downtown |
 | Days Inn Dover Durham Downtown Hotel Portsmouth - NH | 3.0 star rating | 50 | Dover |
| Fairfield Inn Portsmouth Seacoast Hotel Portsmouth - NH | 3.0 star rating | 105 | Downtown |
| Fairfield Inn & Suites by Marriott Portsmouth Exet Hotel Portsmouth - NH | 3.0 star rating | 71 | Downtown |
| Hampton Inn and SuitesPortsmouth/Downtown Hotel Portsmouth - NH | 2.0 star rating | 120 | Downtown |
 | Hampton Inn Dover, NH Hotel Portsmouth - NH | 3.0 star rating | 93 | Dover |
 | Hampton Inn Portsmouth Hotel Portsmouth - NH | 3.0 star rating | 125 | Downtown |
 | Hampton Inn & Suites Exeter Hotel Portsmouth - NH | 3.0 star rating | 111 | Downtown |
 | Hilton Garden Inn Portsmouth Downtown Hotel Portsmouth - NH | 3.0 star rating | 131 | Downtown |
| Holiday Inn Express Durham UNH Hotel Portsmouth - NH | 3.0 star rating | | Dover |
 | Holiday Inn Portsmouth Hotel Portsmouth - NH | 3.0 star rating | 130 | Downtown |
 | Homewood Suites by Hilton Dover Hotel Portsmouth - NH | 3.0 star rating | 88 | Dover |
 | Homewood Suites by Hilton Portsmouth Hotel Portsmouth - NH | 3.0 star rating | 116 | Downtown |
| Howard Johnson Portsmouth Hotel Portsmouth - NH | 2.0 star rating | | Downtown |
 | Microtel Inn & Suites Dover Hotel Portsmouth - NH | 3.0 star rating | 57 | Dover |
 | Motel 6 Portsmouth Hotel Portsmouth - NH | 2.0 star rating | 108 | Downtown |
| Residence Inn Portsmouth Hotel Portsmouth - NH | 3.0 star rating | 90 | Downtown |
| Residence Inn Portsmouth Downtown/Waterfront Hotel Portsmouth - NH | 3.0 star rating | 128 | Downtown |
 | Sheraton Portsmouth Harborside Hotel Portsmouth - NH | 4.0 star rating | 200 | Downtown |
| The Garrison Hotel, an Ascend Hotel Collection Mem Portsmouth - NH | Without Official Category | | Dover |
| The Port Inn Hotel Portsmouth - NH | 3.0 star rating | 56 | Downtown |
| Wentworth by the Sea, A Marriott Hotel & Spa Portsmouth - NH | 4.0 star rating | 161 | New Castle |