 | ACHAT Comfort Frankenthal/Pfalz Hotel Mannheim | 3.0 star rating | 124 | Ludwigshafen |
 | ACHAT Comfort Mannheim/Hockenheim Hotel | 3.0 star rating | 102 | Mannheim |
 | Achat Premium Neustadt Weinstrasse Hotel Mannheim | 4.0 star rating | | Mannheim |
| Alleehotel Europa Hotel Mannheim | 3.0 star rating | 155 | Mannheim |
 | Best Western Delta Park Hotel Mannheim | 3.0 star rating | 129 | Mannheim |
 | Best Western Hotel Ludwigshafen Mannheim | 4.0 star rating | 192 | Ludwigshafen |
 | Best Western Hotel Mannheim City | 3.0 star rating | 162 | Mannheim |
 | Best Western Parkhotel Krone Hotel Mannheim | 4.0 star rating | 68 | Mannheim |
 | Best Western Premier Hotel Lanzcarre Mannheim | 3.0 star rating | 82 | Mannheim |
 | Best Western Premier Steubenhof Hotel Mannheim | 3.0 star rating | 80 | Mannheim |
 | Best Western Victor'S Residenz Hotel Mannheim | 3.0 star rating | 104 | Mannheim |
 | Dorint Kongresshotel Mannheim Hotel | 4.0 star rating | 287 | Mannheim |
 | Excelsior Ludwigshafen Hotel Mannheim | 3.0 star rating | 160 | Ludwigshafen |
| Formule 1 Mannheim Süd Ost Heidelberg Hotel | 3.0 star rating | 70 | Mannheim |
 | IntercityHotel Mannheim | 4.0 star rating | 155 | Mannheim |
| Landhotel Bechtel Hotel Mannheim | 3.0 star rating | 11 | Worms |
 | Leonardo Hotel Mannheim City Center | 4.0 star rating | 146 | Mannheim |
 | Leonardo Hotel Mannheim Ladenburg | 4.0 star rating | 128 | Mannheim |
 | Leonardo Royal Hotel Mannheim | Superior 4* | 192 | Mannheim |
 | Maritim Hotel Mannheim | 4.0 star rating | 187 | Mannheim |
 | Mercure Hotel Bensheim Mannheim | 4.0 star rating | 108 | Mannheim |
 | Mercure Hotel Mannheim am Friedensplatz | 4.0 star rating | 180 | Mannheim |
| Mercure Hotel Mannheim am Rathaus | 3.0 star rating | 150 | Mannheim |
 | NH Mannheim Viernheim Hotel | 4.0 star rating | 121 | Mannheim |
| Parkhotel Prinz Carl Hotel Mannheim | 4.0 star rating | 90 | Worms |
 | Ramada Hockenheim Hotel Mannheim | 3.0 star rating | 80 | Mannheim |
 | Ramada Lampertheim Hotel Mannheim | 3.0 star rating | 67 | Worms |
 | Ramada Mannheim Hotel | 3.0 star rating | 62 | Mannheim |
| Residenz Limburgerhof Hotel Mannheim | 3.0 star rating | 132 | Ludwigshafen |
 | Residenz Mandelgarten Deidesheim Hotel Mannheim | 3.0 star rating | | Deidesheim |
| Schloss Edesheim Hotel Mannheim | 3.0 star rating | 39 | Deidesheim |
 | Steigenberger Hotel Deidesheim . Mannheim | 5.0 star rating | 123 | Deidesheim |
 | Wyndham Mannheim Hotel | 4.0 star rating | 151 | Mannheim |