| Nicoleport Hotel Istanbul | Apartment 1st Category | 9 | New City |
 | Niconya Port Suites & Hotel Istanbul | Boutique | 52 | New City |
 | Nidya Hotel Esenyurt Istanbul | 4.0 star rating | 83 | Ataturk Airport Istanbul |
 | Nidya Hotel Galataport Istanbul | 4.0 star rating | 90 | Old City |
| Nif Hotel Istanbul | 3.0 star rating | 21 | Ataturk Airport Istanbul |
 | Nil Hotel Istanbul | Boutique | 28 | New City |
 | Nippon Hotel Istanbul | 4.0 star rating | 171 | New City |
| Nisantasi Troya Stroy Hotel Istanbul | Aparthotel 3* | 10 | New City |
 | Noahs Ark Hotel Istanbul | Boutique | 18 | Old City |
 | Nobel Hotel Istanbul | 3.0 star rating | 30 | Old City |
 | Noble22 Suites Hotel Istanbul | 3.0 star rating | 22 | Old City |
| Nomade Hotel Istanbul | 3.0 star rating | 16 | Old City |
 | Nordstern Hotel Galata Istanbul | Boutique | 18 | Old City |
 | Nova Plaza Boutique & Spa Hotel Istanbul | 4.0 star rating | 44 | New City |
 | Nova Plaza Taksim Square Hotel Istanbul | 4.0 star rating | 96 | New City |
 | Novotel Istanbul Bosphorus Hotel | 5.0 star rating | 200 | Old City |
 | Novotel Istanbul Zeytinburnu Hotel | 4.0 star rating | 208 | Ataturk Airport Istanbul |
 | Nowy Efendi Hotel Istanbul | Boutique | 28 | Old City |
 | Nuru Ziya Suites Hotel Istanbul | Aparthotel 3* | 18 | New City |
 | Oban Suites Istanbul Hotel | Boutique | 13 | Old City |
 | Occidental The Public Hotel Istanbul | Boutique | 52 | New City |
| Oceans 7 Hotel Istanbul | Standard | 15 | Old City |
 | Odda Hotel Istanbul | Boutique | 28 | New City |
| Old City Apart Hotel Istanbul | 3.0 star rating | 22 | New City |
 | Old City Family Hotel Istanbul | Boutique | 14 | Old City |
 | Old Panorama Hotel Istanbul | Boutique | 14 | Old City |
 | Olimpiyat Hotel Istanbul | 3.0 star rating | 59 | Old City |
 | Opera Hotel Bosphorus Istanbul | 4.0 star rating | 75 | New City |
 | Oran Hotel Istanbul | 4.0 star rating | 89 | Old City |
 | Orient Express Hotel Istanbul | 4.0 star rating | 52 | Old City |
 | Orient Mintur Hotel Istanbul | 3.0 star rating | 43 | Old City |
 | Orka Royal Hotel Istanbul | 4.0 star rating | 117 | Old City |
 | Ortakoy Aparts Hotel Istanbul | Aparthotel 2* | 12 | New City |
 | Ortakoy Princess Hotel Istanbul | 5.0 star rating | 102 | New City |
| Osmanbey Fatih Hotel Istanbul | 3.0 star rating | 48 | New City |
 | Ottoman Elegance Hotel Istanbul | 3.0 star rating | 22 | Old City |
| Ottoman Hotel Cagaloglu Istanbul | Boutique | 34 | Old City |
 | Ottoman Hotel Imperial Istanbul | Boutique | 49 | Old City |
 | Ottoman Hotel Park Istanbul | Boutique | 38 | Old City |
 | Ottoman Luxury Hotel Istanbul | 3.0 star rating | 12 | Old City |
 | Ottoman Palace Taksim Square Hotel Istanbul | 4.0 star rating | 88 | New City |
 | Ottomans Life Hotel Istanbul | Boutique | 32 | Old City |
 | Ottoman Tulip Hotel Istanbul | Boutique | 14 | Old City |
 | Ottopera Hotel Istanbul | 3.0 star rating | 18 | New City |
 | Palazzo Donizetti Hotel Istanbul | 4.0 star rating | 79 | New City |
| Paradise Hotel Istanbul | 3.0 star rating | 8 | New City |
| Park 156 Hotel Istanbul | 3.0 star rating | 18 | Asian Side |
 | Park Dedeman Bostanci Hotel Istanbul | 4.0 star rating | 110 | Asian Side |
 | Park Dedeman Levent Hotel Istanbul | 4.0 star rating | 232 | New City |
| Parkhouse Hotel & Spa Istanbul | 4.0 star rating | 30 | Old City |