 | Baymont Inn & Suites Florence Hotel Florence - SC | 3.0 star rating | 116 | Florence |
 | Best Western Executive Inn Hotel Florence - SC | 3.0 star rating | 58 | Latta |
 | Best Western Inn Hotel Florence - SC | 3.0 star rating | 74 | Florence |
 | Comfort Inn Hotel Florence - SC | 2.0 star rating | 65 | Dillon |
 | Comfort Suites Hotel Florence - SC | 3.0 star rating | 77 | Florence |
 | Days Inn Dillon Hotel Florence - SC | 3.0 star rating | 49 | Dillon |
 | Days Inn Florence / I-95 North Hotel Florence - SC | 3.0 star rating | 103 | Florence |
 | Days Inn Florence Near Civic Center Hotel Florence - SC | 3.0 star rating | 129 | Florence |
| Days Inn Lake City Hotel Florence - SC | Without Official Category | | Lake City |
| Days Inn Summerton Hotel Florence - SC | 2.0 star rating | | Summerton |
| Days Inn Sumter Hotel Florence - SC | 1 Star And A Half | | Sumter |
 | Econo Lodge Hotel Florence - SC | 1 Star And A Half | 162 | Florence |
| Econo Lodge Hotel Florence - SC | 3.0 star rating | 48 | Bishopville |
| Econo Lodge Hotel Florence - SC | 3.0 star rating | 46 | Dillon |
 | Hampton Inn and Suites Hartsville, SC Hotel Florence - SC | 2.0 star rating | 90 | Hartsville |
 | Hampton Inn & Suites Florence-Civic Center Hotel Florence - SC | 3.0 star rating | 82 | Florence |
 | Hampton Inn & Suites Florence-North-I-95 Hotel Florence - SC | 3.0 star rating | 136 | Florence |
 | Hilton Inn Garden Florence Hotel Florence - SC | 3.0 star rating | 186 | Florence |
| Holiday Inn Express and Suites Florence I 95 and I Hotel Florence - SC | 3.0 star rating | | Florence |
| Holiday Inn Express and Suites Florence I 95 at Hw Hotel Florence - SC | 3.0 star rating | | Florence |
| Holiday Inn Express and Suites Sumter Hotel Florence - SC | 3.0 star rating | | Sumter |
| Home2 Suites Florence Hotel Florence - SC | 3.0 star rating | 83 | Florence |
| Hotel Florence, an Ascend Hotel Collection Member Florence - SC | 3.0 star rating | 64 | Florence |
 | Howard Johnson Inn Florence Hotel Florence - SC | 3.0 star rating | 179 | Florence |
| Knights Inn Manning SC Hotel Florence - SC | 2.0 star rating | | Sumter |
 | Microtel Inn & Suites Florence Hotel Florence - SC | 3.0 star rating | 83 | Florence |
| Quality Inn Hotel Florence - SC | 3.0 star rating | 124 | Sumter |
| Quality Inn Hotel Florence - SC | 3.0 star rating | 60 | Manning |
| Quality Inn Hotel Florence - SC | 3.0 star rating | 66 | Hartsville |
 | Quality Inn Hotel Florence - SC | 4.0 star rating | | Mullins |
| Quality Inn Hotel Florence - SC | 3.0 star rating | 55 | Mullins |
| Quality Inn Hotel Florence - SC | 3.0 star rating | 50 | Dillon |
 | Quality Inn & Suites Civic Center Hotel Florence - SC | 2.0 star rating | 80 | Florence |
 | Ramada Florence Center Hotel Florence - SC | 3.0 star rating | 190 | Florence |
 | Red Roof Inn Florence - Civic Center Hotel Florence - SC | 2.0 star rating | | Florence |
| Residence Inn Florence Hotel Florence - SC | 3.0 star rating | | Florence |
 | Rodeway Inn North Hotel Florence - SC | 2.0 star rating | 60 | Florence |
 | Sleep Inn Hotel Florence - SC | 2.0 star rating | 106 | Florence |
 | SpringHill Suites by Marriott Sumter Hotel Florence - SC | 4.0 star rating | 91 | Sumter |
 | Suburban Extended Stay Hotel Florence - SC | 2.0 star rating | 167 | Florence |
| Sunset Inn Manning Hotel Florence - SC | 3.0 star rating | | Manning |
| Super 8 Manning Hotel Florence - SC | 2.0 star rating | 38 | Manning |
 | Super 8 Motel - Dillon Hotel Florence - SC | 3.0 star rating | | Dillon |
 | Super 8 Motel - Florence Hotel Florence - SC | 3.0 star rating | 67 | Florence |
| TownePlace Suites by Marriott Florence Hotel Florence - SC | 4.0 star rating | 94 | Florence |
 | Travelodge Florence Hotel Florence - SC | 3.0 star rating | 110 | Florence |