| Resort Portoselvaggio Puglia | 4.0 star rating | 109 | Salento |
 | Resort Villa Hermosa Puglia | 4.0 star rating | 50 | Lecce |
 | Risorgimento Resort Puglia | 5.0 star rating | 47 | Lecce |
 | Ristoppia Resort Puglia | 4.0 star rating | 76 | Lecce |
 | Riva Marina Resort Puglia | 4.0 star rating | 371 | Brindisi |
 | Rivazzurra Club - Residence Village Hotel Puglia | 3.0 star rating | 47 | Otranto |
 | Riviera Hotel Residence Puglia | 3.0 star rating | 55 | Gargano |
 | Robinson Club Apulia Hotel Puglia | 4.0 star rating | 397 | Ugento |
 | Rodia Hotel Puglia | 3.0 star rating | 45 | Otranto |
 | Rondo Hotel Puglia | 3.0 star rating | 62 | Bari |
 | Rosa Marina Grand Hotel Puglia | 4.0 star rating | 240 | Ostuni |
 | Rosangela - Two Bedroom Hotel Puglia | Without Official Category | | Brindisi |
 | Royals Gate Hotel Puglia | 4.0 star rating | 70 | Gargano |
 | Saint Nicholas Plaza Hotel Puglia | 3.0 star rating | 4 | Bari |
 | Sairon Village Hotel Puglia | 4.0 star rating | 121 | Torre dell Orso |
 | Salsello Hotel Puglia | 4.0 star rating | 49 | Bari |
 | Sangiorgio Resort & Spa Puglia | 5.0 star rating | 18 | Lecce |
 | San Giovanni - One Bedroom Hotel Puglia | Without Official Category | | Salento |
 | San Giuseppe Hotel Puglia | 4.0 star rating | 19 | Otranto |
 | San Luca - One Bedroom Hotel Puglia | Without Official Category | | Gargano |
 | San Luca - One Bedroom No.2 Hotel Puglia | Without Official Category | | Gargano |
 | San Luca - One Bedroom No.3 Hotel Puglia | Without Official Category | | Gargano |
 | San Luca - Two Bedroom Hotel Puglia | Without Official Category | | Gargano |
| Sanlu Hotel Puglia | 3.0 star rating | 30 | Otranto |
 | San Nicola Hotel Puglia | 3.0 star rating | 24 | Bari |
| San Paolo Al Convento Hotel Puglia | 4.0 star rating | 32 | Trani |
| Santa Caterina Resort & Spa Puglia | 4.0 star rating | 22 | Salento |
 | Santacroce Luxury Rooms Hotel Puglia | 3.0 star rating | 5 | Lecce |
| Santa Lucia Hotel Puglia | Bed And Breakfast | 27 | San Giovanni Rotondo |
| Savonarola Apartment - One Bedroom Hotel Puglia | Without Official Category | | Salento |
| Savonarola Big Apartment - Two Bedroom Hotel Puglia | Without Official Category | | Salento |
| Sax House - Two Bedroom Hotel Puglia | Without Official Category | | Lecce |
 | Scala H - One Bedroom Hotel Puglia | Without Official Category | | Salento |
| Sea Dreams House - One Bedroom Hotel Puglia | Without Official Category | | Ugento |
 | Semiramide Palace Hotel Puglia | 4.0 star rating | 66 | Bari |
 | Serra Degli Alimini 1 Hotel Puglia | 3.0 star rating | | Otranto |
 | SEVEN SUITE Hotel Puglia | 3.0 star rating | 10 | Gallipoli |
| Sierra Silvana Hotel Puglia | 4.0 star rating | 120 | Fasano |
| Silvana Hotel & Residence Puglia | 3.0 star rating | 12 | Taranto |
 | Spiaggia Lunga Villaggio Hotel Puglia | 3.0 star rating | 250 | Gargano |
| Spinola Hotel Puglia | 3.0 star rating | 16 | Lecce |
 | Sud Hotel Puglia | 3.0 star rating | | Taranto |
| Suite Hotel Santa Chiara Puglia | 4.0 star rating | 21 | Lecce |
| SUITE PORTA TERRA GALLIPOLI Hotel Puglia | 3.0 star rating | | Lecce |
 | Sun Beach Villa - Two Bedroom Hotel Puglia | Without Official Category | | Lecce |
 | Sun & Sea Terrace - One Bedroom Hotel Puglia | Without Official Category | | Salento |
 | Sun & Sea Terrace - Two Bedroom Hotel Puglia | Without Official Category | | Salento |
 | Tenuta Barco Di Eméra Hotel Puglia | Rural Hotel | 24 | Taranto |
| Tenuta Monacelle Hotel Puglia | 3.0 star rating | 36 | Bari |
 | Tenuta Monacelle Hotel Puglia | 4.0 star rating | 36 | Fasano |