 | Albatros Hotel Karpathos | 3.0 star rating | 36 | Amoopi |
| Alex Hotel Karpathos | 2.0 star rating | 25 | Pigadia |
 | Alimounda Mare Hotel Karpathos | 5.0 star rating | 244 | Pigadia |
 | Alpha Hotel Karpathos | 3.0 star rating | | Arkassa |
 | Althea Boutique Hotel Karpathos | 3.0 star rating | 1 | Amoopi |
| Apolis Hotel Karpathos | 4.0 star rating | 35 | Amoopi |
| Archipelagos Hotel Karpathos | 3.0 star rating | | Arkassa |
 | Archontiko Hotel Karpathos | 3.0 star rating | 12 | Faniki |
 | Argo Hotel Karpathos | 3.0 star rating | 48 | Amoopi |
| Arkasa Bay Hotel Karpathos | 4.0 star rating | 18 | Arkassa |
 | Astron Hotel Karpathos | 3.0 star rating | 82 | Pigadia |
| Athena Palace Hotel Karpathos | 3.0 star rating | 14 | Arkassa |
 | Atlantis Hotel Karpathos | 2.0 star rating | 38 | Pigadia |
 | Balaskas Hotel Karpathos | 2.0 star rating | 19 | Diafani |
 | Blue Bay Hotel Karpathos | 2.0 star rating | 6 | Pigadia |
 | Blue Horizon Hotel Karpathos | 3.0 star rating | 8 | Lefkos |
| Blue Sea Hotel Karpathos | 3.0 star rating | | Amoopi |
 | Dorana Hotel Karpathos | 2.0 star rating | 14 | Diafani |
 | Glaros Hotel Karpathos | 2.0 star rating | 16 | Diafani |
| Golden Sun Hotel Karpathos | 3.0 star rating | 12 | Arkassa |
 | Iolkos Hotel Karpathos | 2.0 star rating | 38 | Pigadia |
 | Irini Hotel Karpathos | 3.0 star rating | 289 | Afiatis |
 | Konstantinos Palace Hotel Karpathos | 4.0 star rating | | Pigadia |
| Krinos Hotel Karpathos | 3.0 star rating | | Lefkos |
 | Kyra Panagia Hotel Karpathos | 3.0 star rating | 34 | Kyra Panagia |
 | Lefkorama Hotel Karpathos | 3.0 star rating | 11 | Lefkos |
| Maria Studios & Apartments Hotel Karpathos | 2 Keys | | Amoopi |
| Mediterranean Hotel Karpathos | 3.0 star rating | 35 | Pigadia |
| Mikes Apartments Hotel Karpathos | 4.0 star rating | | Pigadia |
 | Miraluna Hotel Karpathos | 3.0 star rating | 7 | Lefkos |
 | Miramare Bay Hotel Karpathos | 3.0 star rating | 43 | Pigadia |
| Montemar Studios Hotel Karpathos | 2 Keys | | Arkassa |
 | Nereides Hotel Karpathos | 4.0 star rating | 11 | Pigadia |
| Oceanis Hotel Karpathos | 2.0 star rating | 55 | Pigadia |
 | Olympic Hotel Karpathos | 2.0 star rating | 41 | Pigadia |
| Panorama Hotel Karpathos | 2.0 star rating | | Pigadia |
| Petra House Hotel Karpathos | 4.0 star rating | 1 | Pigadia |
| Potali Bay Hotel Karpathos | 3.0 star rating | 12 | Lefkos |
 | Regina Hotel Karpathos | 2.0 star rating | 28 | Pigadia |
 | Royal Mare Hotel Karpathos | 4.0 star rating | | Arkassa |
 | Seven Stars Hotel Karpathos | 3.0 star rating | 60 | Pigadia |
 | Socrates Hotel Karpathos | 4.0 star rating | | Pigadia |
 | Sun Flower Hotel Karpathos | 3 Keys | | Amoopi |
 | Sunrise Hotel Karpathos | 2.0 star rating | 30 | Pigadia |
| Sun Set Hotel Karpathos | 3 Keys | | Lefkos |
 | White Sand Hotel Karpathos | 3.0 star rating | | Lefkos |
 | Yiannis Hotel Karpathos | 2.0 star rating | 19 | Arkassa |